About: The gene for interleukin 6: the candidate gene for neuropsychiatric illness?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. Genetic variation (-174 G/C polymorphism) in the promoter region of the IL-6 gene influences the expression of IL-6. Our objective was to determine whether -174 G/C polymorphism of IL-6 is associated with alcoholism and ADHD. In our two independent association studies, we investigated the relationship between above mentioned polymorphism and alcoholism in 400 alcoholics and 400 controls, and in ADHD study in 49 hyperactive boys and 40 control boys. We found a statistically significant difference (p<0.03) in allelic frequencies between alcoholics and controls and statistically significant difference (p<0.001) between controls and ADHD subjects using Fisher exact test. The C allele was observed more frequently in alcoholics, as well as in ADHD group of boys in comparing with control subjects. Our association studies provided new data about the relationship between -174 G/C pol IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. Genetic variation (-174 G/C polymorphism) in the promoter region of the IL-6 gene influences the expression of IL-6. Our objective was to determine whether -174 G/C polymorphism of IL-6 is associated with alcoholism and ADHD. In our two independent association studies, we investigated the relationship between above mentioned polymorphism and alcoholism in 400 alcoholics and 400 controls, and in ADHD study in 49 hyperactive boys and 40 control boys. We found a statistically significant difference (p<0.03) in allelic frequencies between alcoholics and controls and statistically significant difference (p<0.001) between controls and ADHD subjects using Fisher exact test. The C allele was observed more frequently in alcoholics, as well as in ADHD group of boys in comparing with control subjects. Our association studies provided new data about the relationship between -174 G/C pol (en) IL-6 je kandidátním genem neuropsychiatrických poruch. Nalezli jsme vztah polymorfizmu tohoto genu k ADHD i alkoholizmu. Další studium by mělo tento vztah vyvrátit nebo potvrdit. (cs)
Title	The gene for interleukin 6: the candidate gene for neuropsychiatric illness? Gen pro interleukin 6: kandidátní gen neuropsychiatrických chorob? (cs) The gene for interleukin 6: the candidate gene for neuropsychiatric illness? (en)
skos:prefLabel	The gene for interleukin 6: the candidate gene for neuropsychiatric illness? Gen pro interleukin 6: kandidátní gen neuropsychiatrických chorob? (cs) The gene for interleukin 6: the candidate gene for neuropsychiatric illness? (en)
skos:notation	RIV/00216224:14310/06:00017435!RIV08-MSM-14310___
http://linked.open.../vavai/riv/strany	728
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8137), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Pitelová, Renáta Šerý, Omar Drtílková, Ivana Lochman, Jan Mikeš, Vladimír Štaif, Radim Zvolský, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	476763
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00017435
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IL-6; polymorphism; alcohol dependence; ADHD (en)
http://linked.open.../riv/klicoveSlovo	IL-6 ADHD polymorphism alcohol dependence
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[87C00D4CCDCC]
http://linked.open...i/riv/nazevZdroje	American Journal of Medical Genetics
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular causes of dispositions to alcoholism.
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	141B
http://linked.open...iv/tvurceVysledku	Drtílková, Ivana Zvolský, Petr Šerý, Omar Lochman, Jan Mikeš, Vladimír Štaif, Radim Pitelová, Renáta
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	1552-4841
number of pages	1 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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