About: Trapped water molecules are essential to structural dynamics and function of a ribozyme

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network. Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network. (en)
Title	Trapped water molecules are essential to structural dynamics and function of a ribozyme Trapped water molecules are essential to structural dynamics and function of a ribozyme (en)
skos:prefLabel	Trapped water molecules are essential to structural dynamics and function of a ribozyme Trapped water molecules are essential to structural dynamics and function of a ribozyme (en)
skos:notation	RIV/00216224:14310/06:00017097!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA203/05/0009), P(GA203/05/0388), P(LC06030), P(LC512), Z(AV0Z40550506), Z(AV0Z50040507), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	36
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šponer, Jiří Réblová, Kamila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	504308
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00017097
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	coupled molecular motions; hairpin ribozyme; molecular dynamics; proton wire (en)
http://linked.open.../riv/klicoveSlovo	molecular dynamics hairpin ribozyme coupled molecular motions proton wire
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F15723AE749A]
http://linked.open...i/riv/nazevZdroje	The Proceedings of the National Academy of Sciences
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Biomolecular centre Center for biomolecules and complex molecular systems Structure and dynamics of DNA nitrogeneous bases, base pairs, oligonucleotides and their complexes with water, ions and drugs Conformational dynamics of nucleic acids
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	103
http://linked.open...iv/tvurceVysledku	Réblová, Kamila Šponer, Jiří Nils, Walter Rhodes, Maria
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Biophysics of dynamic structures and functions of biological systems Proteiny v metabolismu a při interakci organismů s prostředím
issn	1091-6490
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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