About: The association of monoamine oxidase B functional polymorphism with postoperative pain intensity

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About: The association of monoamine oxidase B functional polymorphism with postoperative pain intensity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objectives: The monoamine oxidase B (MAO-B) is an enzyme involved in metabolism of dopamine, benzylamine, phenylethylamine, tyramine and tryptamine. The A/G polymorphism in intron 13 of the MAO-B gene has been previously found to be associated with variability of the MAO-B enzyme activity. The aim of the present association study has been to examine the relationship between the A/G polymorphism in intron 13 and postoperative pain intensity. Methods: 284 subjects (105 males and 179 females) undergoing planned tonsillectomy were examined. The intensity of pain was evaluated using 100-mm visual analogue scale (VAS). A PCR method with allele specific primers for detection of A/G polymorphism was used. Results: We found a relationship between the A/G polymorphism in intron 13 of the MAO-B gene and average intensity of postoperative pain in male subjects. Higher average intensity of postoperative pain was detected in males with the G allele (3.96) in comparison with males with the A allele (3. Objectives: The monoamine oxidase B (MAO-B) is an enzyme involved in metabolism of dopamine, benzylamine, phenylethylamine, tyramine and tryptamine. The A/G polymorphism in intron 13 of the MAO-B gene has been previously found to be associated with variability of the MAO-B enzyme activity. The aim of the present association study has been to examine the relationship between the A/G polymorphism in intron 13 and postoperative pain intensity. Methods: 284 subjects (105 males and 179 females) undergoing planned tonsillectomy were examined. The intensity of pain was evaluated using 100-mm visual analogue scale (VAS). A PCR method with allele specific primers for detection of A/G polymorphism was used. Results: We found a relationship between the A/G polymorphism in intron 13 of the MAO-B gene and average intensity of postoperative pain in male subjects. Higher average intensity of postoperative pain was detected in males with the G allele (3.96) in comparison with males with the A allele (3. (en)
Title	The association of monoamine oxidase B functional polymorphism with postoperative pain intensity The association of monoamine oxidase B functional polymorphism with postoperative pain intensity (en)
skos:prefLabel	The association of monoamine oxidase B functional polymorphism with postoperative pain intensity The association of monoamine oxidase B functional polymorphism with postoperative pain intensity (en)
skos:notation	RIV/00216224:14310/06:00016778!RIV10-MZ0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NM7146), Z(MSM0021620806), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šerý, Omar Hrazdilová, Olga Ševčík, Pavel Štaif, Radim Znojil, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	466195
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00016778
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	association; MAOB; pain; polymorphism; gene (en)
http://linked.open.../riv/klicoveSlovo	pain association gene polymorphism MAOB
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2E4C479E54BF]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic base of acute pain perception
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Ševčík, Pavel Šerý, Omar Klenerová, Věra Štaif, Radim Znojil, Vladimír Hrazdilová, Olga
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Proteiny v metabolismu a při interakci organismů s prostředím
issn	0172-780X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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