About: PIN proteins perform a rate-limiting function in cellular auxin efflux

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About: PIN proteins perform a rate-limiting function in cellular auxin efflux Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Intercellular flow of the phytohormone auxin underpins multiple developmental processes in plants. Plant-specific PIN proteins and several PGP transporters are crucial factors in auxin transport-related development, yet PINs molecular function remains unknown. Here we show that PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. Conditional gain-of-function alleles and quantitative measurements of auxin accumulation in Arabidopsis and tobacco cultured cells revealed that the action of PINs in auxin efflux is distinct from PGPs, rate-limiting, specific to auxins and sensitive to auxin transport inhibitors. This suggests a direct involvement of PINs in catalyzing cellular auxin efflux. Intercellular flow of the phytohormone auxin underpins multiple developmental processes in plants. Plant-specific PIN proteins and several PGP transporters are crucial factors in auxin transport-related development, yet PINs molecular function remains unknown. Here we show that PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. Conditional gain-of-function alleles and quantitative measurements of auxin accumulation in Arabidopsis and tobacco cultured cells revealed that the action of PINs in auxin efflux is distinct from PGPs, rate-limiting, specific to auxins and sensitive to auxin transport inhibitors. This suggests a direct involvement of PINs in catalyzing cellular auxin efflux. (en)
Title	PIN proteins perform a rate-limiting function in cellular auxin efflux PIN proteins perform a rate-limiting function in cellular auxin efflux (en)
skos:prefLabel	PIN proteins perform a rate-limiting function in cellular auxin efflux PIN proteins perform a rate-limiting function in cellular auxin efflux (en)
skos:notation	RIV/00216224:14310/06:00016660!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA6038303), P(LC06034), Z(AV0Z50380511), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	Apr 6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Friml, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	492149
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00016660
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	auxin transport; auxin efflux; PIN proteins; Arabidopsis (en)
http://linked.open.../riv/klicoveSlovo	auxin transport auxin efflux Arabidopsis PIN proteins
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[ECF5E67065E8]
http://linked.open...i/riv/nazevZdroje	Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	21 (xsd:int)
http://linked.open...vavai/riv/projekt	Regulation of morphogenesis of plant cells and organs Transmembrane transport of plant growth substances in plant cells
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	2006
http://linked.open...iv/tvurceVysledku	Dhonukshe, P. Friml, Jiří Mravec, J. Petrášek, J. Benková, E. Murphy, A. Blakeslee, J. Geisler, M. Zažímalová, E. Bouchard, R. Seifertová, D. Křeček, P. Tadele, Z. Luschnig, C. Wisniewska, J. Abas, M. Fink, G. Lee, O. R. Perry, L. Skůpa, P. Čovanová, M.
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Molecular basis of cell and tissue regulations
issn	0036-8075
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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