About: Polymorphism of DRD2 gene and ADHD     Goto   Sponge   NotDistinct   Permalink

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  • Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys.
  • Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys. (en)
  • Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys. (cs)
Title
  • Polymorphism of DRD2 gene and ADHD
  • Polymorphism of DRD2 gene and ADHD (en)
  • Polymorphism of DRD2 gene and ADHD (cs)
skos:prefLabel
  • Polymorphism of DRD2 gene and ADHD
  • Polymorphism of DRD2 gene and ADHD (en)
  • Polymorphism of DRD2 gene and ADHD (cs)
skos:notation
  • RIV/00216224:14310/06:00016583!RIV10-MZ0-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NF6520), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 492880
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/06:00016583
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ADHD; dopamine; DRD2; polymorphism; association; gene (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [DF2423FC49FF]
http://linked.open...i/riv/nazevZdroje
  • Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Drtílková, Ivana
  • Šerý, Omar
  • Lochman, Jan
  • Theiner, Pavel
  • Štaif, Radim
  • Pitelová, Renáta
  • Znojil, Vladimír
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-780X
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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