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  • For studying the disruption, we used new in vitro method with the cell line P19/A15. It is murine embryonal P19 cell line stably transfected with luciferase reporter gene under the control of RARE (Retinoic Acid Responsive Element). Xenobiotics potentially interacting with the retinoid signaling can either induce luciferase expression and/or negatively affect retinoic acid (ATRA)-induced luciferase activity. For our study we selected the group of PAH and their N-heterocyclic analogs especially for their widespread environmental occurrence and possible teratogenic effects. We tested 13 N-PAHs and 6 PAHs for retinoid and antiretinoid activity.
  • For studying the disruption, we used new in vitro method with the cell line P19/A15. It is murine embryonal P19 cell line stably transfected with luciferase reporter gene under the control of RARE (Retinoic Acid Responsive Element). Xenobiotics potentially interacting with the retinoid signaling can either induce luciferase expression and/or negatively affect retinoic acid (ATRA)-induced luciferase activity. For our study we selected the group of PAH and their N-heterocyclic analogs especially for their widespread environmental occurrence and possible teratogenic effects. We tested 13 N-PAHs and 6 PAHs for retinoid and antiretinoid activity. (en)
Title
  • INTERFERENCE OF PAHs AND THEIR DERIVATIVES WITH SIGNALING OF RETINOIDS
  • INTERFERENCE OF PAHs AND THEIR DERIVATIVES WITH SIGNALING OF RETINOIDS (en)
skos:prefLabel
  • INTERFERENCE OF PAHs AND THEIR DERIVATIVES WITH SIGNALING OF RETINOIDS
  • INTERFERENCE OF PAHs AND THEIR DERIVATIVES WITH SIGNALING OF RETINOIDS (en)
skos:notation
  • RIV/00216224:14310/06:00016464!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP525/05/P160), Z(MSM0021622412)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 480079
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/06:00016464
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • PAHs; retinoid; RAR/RXR; embryotoxicity; retinoic acid (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [508B6F30D912]
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Bláha, Luděk
  • Hilscherová, Klára
  • Pacherník, Jiří
  • Beníšek, Martin
http://linked.open...n/vavai/riv/zamer
http://localhost/t...ganizacniJednotka
  • 14310
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