About: Cisplatin electrochemical biosensor

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Platinum complexes play an important role in the chemotherapy of various tumour diseases. The aim of this paper was to investigate if a metallothionein (MT) modified hanging mercury drop electrode can be applied as a cisplatin electrochemical biosensor. The modification of the mercury electrode surface by MT and the determination of cisplatin were performed by adsorptive transfer stripping technique and differential pulse voltammetry. The detection limit (3 S/N) of cisplatin ([Pt-II(NH3)(2)Cl-2](0)) calculated from the decrease of CdT peak was about 2.5 pmol in 5 mu l (0.5 mu M) at the interaction time of 400 s. Moreover, we tested the influence of human blood serum as a complex biological matrix on the way of determination of cisplatin. On the basis of the obtained results we estimated that we are able to determine tens of picomoles of cisplatin (5 mu l drop) in the presence of human blood serum. Platinum complexes play an important role in the chemotherapy of various tumour diseases. The aim of this paper was to investigate if a metallothionein (MT) modified hanging mercury drop electrode can be applied as a cisplatin electrochemical biosensor. The modification of the mercury electrode surface by MT and the determination of cisplatin were performed by adsorptive transfer stripping technique and differential pulse voltammetry. The detection limit (3 S/N) of cisplatin ([Pt-II(NH3)(2)Cl-2](0)) calculated from the decrease of CdT peak was about 2.5 pmol in 5 mu l (0.5 mu M) at the interaction time of 400 s. Moreover, we tested the influence of human blood serum as a complex biological matrix on the way of determination of cisplatin. On the basis of the obtained results we estimated that we are able to determine tens of picomoles of cisplatin (5 mu l drop) in the presence of human blood serum. (en)
Title	Cisplatin electrochemical biosensor Cisplatin electrochemical biosensor (en)
skos:prefLabel	Cisplatin electrochemical biosensor Cisplatin electrochemical biosensor (en)
skos:notation	RIV/00216224:14310/06:00016155!RIV10-GA0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP525/04/P132)
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Trnková, Libuše Adam, Vojtěch Zehnálek, Josef Kizek, René Potěšil, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	468794
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00016155
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cisplatin; electrochemical biosensor (en)
http://linked.open.../riv/klicoveSlovo	Cisplatin electrochemical biosensor
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C8D89B90A2F5]
http://linked.open...i/riv/nazevZdroje	Electrochim. Acta
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of protection mechanisms for stress-induced by heavy metals
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Kizek, René Trnková, Libuše Zehnálek, Josef Petrlová, Jitka Potěšil, David Sures, Berd
issn	0013-4686
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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