About: Role of vimentin in regulation of monocyte/macrophage differentiation

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About: Role of vimentin in regulation of monocyte/macrophage differentiation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We explored the identity and function of an unknown protein that was greatly overexpressed in v-myb-transformed BM2 monoblasts undergoing differentiation to macrophage-like cells. We identified this protein as vimentin, the intermediate filament protein. We show that an increased level of the vimentin protein results from activation of the vimentin gene promoter occurring in monoblastic cells induced to differentiate by multiple agents. Furthermore, our studies reveal that the vimentin gene promoter is stimulated by Myb and Jun proteins, the key transcriptional regulators of myeloid maturation. Silencing of vimentin gene expression using siRNA markedly suppressed the ability of BM2 cells to form macrophage polykaryons active in phagocytosis and producing reactive oxygen species. These findings document that up-regulation of vimentin gene expression is important for formation of fully active macrophage-like cells. We explored the identity and function of an unknown protein that was greatly overexpressed in v-myb-transformed BM2 monoblasts undergoing differentiation to macrophage-like cells. We identified this protein as vimentin, the intermediate filament protein. We show that an increased level of the vimentin protein results from activation of the vimentin gene promoter occurring in monoblastic cells induced to differentiate by multiple agents. Furthermore, our studies reveal that the vimentin gene promoter is stimulated by Myb and Jun proteins, the key transcriptional regulators of myeloid maturation. Silencing of vimentin gene expression using siRNA markedly suppressed the ability of BM2 cells to form macrophage polykaryons active in phagocytosis and producing reactive oxygen species. These findings document that up-regulation of vimentin gene expression is important for formation of fully active macrophage-like cells. (en)
Title	Role of vimentin in regulation of monocyte/macrophage differentiation Role of vimentin in regulation of monocyte/macrophage differentiation (en)
skos:prefLabel	Role of vimentin in regulation of monocyte/macrophage differentiation Role of vimentin in regulation of monocyte/macrophage differentiation (en)
skos:notation	RIV/00216224:14310/06:00015742!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/1055), P(GP301/03/D022), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pelková, Vendula Mužík, Jan Zdráhal, Zbyněk Beneš, Petr Šmarda, Jan Ondroušková, Eva Konečná, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	497922
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00015742
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	vimentin; differentiation; macrophage; phagocytosis; proliferation (en)
http://linked.open.../riv/klicoveSlovo	macrophage vimentin phagocytosis differentiation proliferation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3ED08B0B36FC]
http://linked.open...i/riv/nazevZdroje	Differentiation
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach The role of vimentin in the monocyte/macrophage differentiation pathway
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Beneš, Petr Konečná, Hana Zdráhal, Zbyněk Šmarda, Jan Mužík, Jan Ondroušková, Eva Pelková, Vendula
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0301-4681
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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