About: Toxicological aspects of flavonoid interaction with biomacromolecules

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Flavonoids are widely accepted as health promoting phytochemicals, however, some flavonoids show ability of direct interaction with DNA and/or enhance carcinogen activation into DNA modifying agents. Thus, their potential harmful effect on the human body should be examined in detail. METHODS: Direct interaction of flavonoids (quercetin, rutin) with DNA was examined using square wave voltammetry on carbon paste electrode. Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver. Moreover, synthetic beta-naphthoflavone and naturally occurring chrysin, quercetin and diosmin induced CYP1A1 in both tissues. Flavonoids are widely accepted as health promoting phytochemicals, however, some flavonoids show ability of direct interaction with DNA and/or enhance carcinogen activation into DNA modifying agents. Thus, their potential harmful effect on the human body should be examined in detail. METHODS: Direct interaction of flavonoids (quercetin, rutin) with DNA was examined using square wave voltammetry on carbon paste electrode. Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver. Moreover, synthetic beta-naphthoflavone and naturally occurring chrysin, quercetin and diosmin induced CYP1A1 in both tissues. (en)
Title	Toxicological aspects of flavonoid interaction with biomacromolecules Toxicological aspects of flavonoid interaction with biomacromolecules (en)
skos:prefLabel	Toxicological aspects of flavonoid interaction with biomacromolecules Toxicological aspects of flavonoid interaction with biomacromolecules (en)
skos:notation	RIV/00216224:14310/06:00015538!RIV10-AV0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA303/06/0928), P(GP525/04/P132), P(IAA100040602)
http://linked.open...iv/cisloPeriodika	suppl2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Křížková, Soňa Trnková, Libuše Kizek, René Mikelová, Radka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	504082
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00015538
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Flavonoids; interactions; biomacromolecules (en)
http://linked.open.../riv/klicoveSlovo	interactions Flavonoids biomacromolecules
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B7B61AE3865F]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinol. Lett.
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Study on structure-function relationship of cytochromes P450 - key enzymes involved in drug metabolism and carcinogen activation Study of protection mechanisms for stress-induced by heavy metals New approaches in electrochemical analysis of nucleic acids and oligonucleotides aimed at a ultrasensitive microdetection of DNA and DNA hybridization.
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Beklová, Miroslava Horna, Aleš Kizek, René Křížková, Soňa Trnková, Libuše Mikelová, Radka Hanuštiak, Pavel Stiborová, M. Hodek, P. Křížková, J.
issn	0172-780X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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