About: Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells

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About: Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Polychlorinated biphenyls (PCBs) are an important group of persistent environmental contaminants that exhibit tumor promoting effects in experimental animals. In this study, the effects of six model PCB congeners and hydroxylated PCB metabolites on proliferation of confluent rat liver epithelial stem-like WB-F344 cells were investigated. The data suggest that dioxin-like PCBs can release rat liver epithelial cells from contact inhibition and induce cell proliferation by increasing cyclin A protein levels, which then leads to upregulation of cyclin A/cdk2 activity and initiation of DNA replication. This mechanism could be involved in tumor promoting effects of dioxin-like PCBs. Polychlorinated biphenyls (PCBs) are an important group of persistent environmental contaminants that exhibit tumor promoting effects in experimental animals. In this study, the effects of six model PCB congeners and hydroxylated PCB metabolites on proliferation of confluent rat liver epithelial stem-like WB-F344 cells were investigated. The data suggest that dioxin-like PCBs can release rat liver epithelial cells from contact inhibition and induce cell proliferation by increasing cyclin A protein levels, which then leads to upregulation of cyclin A/cdk2 activity and initiation of DNA replication. This mechanism could be involved in tumor promoting effects of dioxin-like PCBs. (en)
Title	Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells (en)
skos:prefLabel	Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells (en)
skos:notation	RIV/00216224:14310/05:00028367!RIV10-AV0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA525/03/1527), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hampl, Aleš Kozubík, Alois Bryja, Vítězslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	513103
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/05:00028367
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cells (en)
http://linked.open.../riv/klicoveSlovo	cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C68AB5B8AA2B]
http://linked.open...i/riv/nazevZdroje	Toxicological sciences
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Chemical identification and in vitro screening of toxicity of aromatic contaminants in agricultural production environment
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	83
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Hampl, Aleš Kozubík, Alois Machala, M. Vondráček, J. Dietrich, C. Chramostová, K. Krčmár, P.
http://linked.open...ain/vavai/riv/wos	000225677700006
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	1096-6080
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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