About: Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator.

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About: Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cultures of three-dimensional aggregates of embryonic stem (ES) cells called embryoid bodies (EBs) provide a valuable system for analyzing molecular mechanisms that regulate differentiation of this unique cell type. Cyclin dependent kinase inhibitor p27Kip1 (p27) becomes dramatically elevated during the differentiation of mouse ES (mES) cells. In this study, various aspects of differentiation of EBs produced from normal and p27-deficient mES cells were analyzed to address biological significance of this elevation. The data point to a dual role of p27 in mES cells, with one role beeing in the regulation of proliferation and the other role in establishing some other aspects of a differentiated phenotype. Cultures of three-dimensional aggregates of embryonic stem (ES) cells called embryoid bodies (EBs) provide a valuable system for analyzing molecular mechanisms that regulate differentiation of this unique cell type. Cyclin dependent kinase inhibitor p27Kip1 (p27) becomes dramatically elevated during the differentiation of mouse ES (mES) cells. In this study, various aspects of differentiation of EBs produced from normal and p27-deficient mES cells were analyzed to address biological significance of this elevation. The data point to a dual role of p27 in mES cells, with one role beeing in the regulation of proliferation and the other role in establishing some other aspects of a differentiated phenotype. (en)
Title	Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. (en)
skos:prefLabel	Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. (en)
skos:notation	RIV/00216224:14310/05:00021445!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/01/0905), P(GA524/03/0766), P(GP524/03/P171), P(KJB5039301), P(LN00A065), Z(AV0Z5039906), Z(MSM 432100001)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hampl, Aleš Bryja, Vítězslav Horváth, Viktor Pacherník, Jiří Dvořák, Petr Čajánek, Lukáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	511189
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/05:00021445
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cells (en)
http://linked.open.../riv/klicoveSlovo	cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9F53BCF0EA8B]
http://linked.open...i/riv/nazevZdroje	Stem Cells
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair Interactions and functions of cell cycle regulators in cell differentiation Modulation of proliferation, differentiation and apoptosis of hemopoietic cells - interactions of cytokines, drugs and lipid nutrition compounds Mechanisms driving neural differentiation in mouse embryonic stem cells in vitro The role of p27 in differentiation of embryoid bodies
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Dvořák, Petr Hampl, Aleš Horváth, Viktor Pacherník, Jiří Čajánek, Lukáš Hall, A. C.
http://linked.open...ain/vavai/riv/wos	000231374000012
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20432100001 The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	1066-5099
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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