About: Functional analysis of p53 tumor suppressor in yeast

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The p53 tumor suppressor protein is a transcription factor that mediates the cells response to various kinds of stress by preventing cell division and/or inducing apoptosis. p53 gene mutations have been detected in nearly 50% of human cancers. Several approaches have been developed for detection and analyses of p53 mutations: immunochemical methods have been developed to detect p53 protein levels; molecular analyses targeting changes in DNA structure are utilized; and functional assays are used to explore the biological properties of the p53 protein. Functional analysis of separated alleles in yeast targets the transactivation capability of the p53 protein expressed in yeast cells. This method uses p53 mRNA isolated from cells and tissues to produce p53 product by RT-PCR. This method serves as a powerful tool for distinguishing various functional types of p53 mutations. The p53 tumor suppressor protein is a transcription factor that mediates the cells response to various kinds of stress by preventing cell division and/or inducing apoptosis. p53 gene mutations have been detected in nearly 50% of human cancers. Several approaches have been developed for detection and analyses of p53 mutations: immunochemical methods have been developed to detect p53 protein levels; molecular analyses targeting changes in DNA structure are utilized; and functional assays are used to explore the biological properties of the p53 protein. Functional analysis of separated alleles in yeast targets the transactivation capability of the p53 protein expressed in yeast cells. This method uses p53 mRNA isolated from cells and tissues to produce p53 product by RT-PCR. This method serves as a powerful tool for distinguishing various functional types of p53 mutations. (en)
Title	Functional analysis of p53 tumor suppressor in yeast Functional analysis of p53 tumor suppressor in yeast (en)
skos:prefLabel	Functional analysis of p53 tumor suppressor in yeast Functional analysis of p53 tumor suppressor in yeast (en)
skos:notation	RIV/00216224:14310/05:00013878!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Koptíková, Jana Šmarda, Jan Šmardová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	522214
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/05:00013878
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tumor suppressor; p53 mutation; p53 activity; FASAY (en)
http://linked.open.../riv/klicoveSlovo	tumor suppressor p53 mutation FASAY p53 activity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8B97DAF03AD8]
http://linked.open...i/riv/nazevZdroje	Differentiation
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Koptíková, Jana Šmarda, Jan Šmardová, Jana
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0301-4681
number of pages	17 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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