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  • The p53 tumor suppressor protein is a transcription factor that mediates the cells response to various kinds of stress by preventing cell division and/or inducing apoptosis. p53 gene mutations have been detected in nearly 50% of human cancers. Several approaches have been developed for detection and analyses of p53 mutations: immunochemical methods have been developed to detect p53 protein levels; molecular analyses targeting changes in DNA structure are utilized; and functional assays are used to explore the biological properties of the p53 protein. Functional analysis of separated alleles in yeast targets the transactivation capability of the p53 protein expressed in yeast cells. This method uses p53 mRNA isolated from cells and tissues to produce p53 product by RT-PCR. This method serves as a powerful tool for distinguishing various functional types of p53 mutations. Understanding of exact impact of p53 mutation on its function is an important prerequisite for establishment of efficient anticancer
  • The p53 tumor suppressor protein is a transcription factor that mediates the cells response to various kinds of stress by preventing cell division and/or inducing apoptosis. p53 gene mutations have been detected in nearly 50% of human cancers. Several approaches have been developed for detection and analyses of p53 mutations: immunochemical methods have been developed to detect p53 protein levels; molecular analyses targeting changes in DNA structure are utilized; and functional assays are used to explore the biological properties of the p53 protein. Functional analysis of separated alleles in yeast targets the transactivation capability of the p53 protein expressed in yeast cells. This method uses p53 mRNA isolated from cells and tissues to produce p53 product by RT-PCR. This method serves as a powerful tool for distinguishing various functional types of p53 mutations. Understanding of exact impact of p53 mutation on its function is an important prerequisite for establishment of efficient anticancer (en)
  • Nádorový supresor p53 je transkripční faktor zprostředkovávající odpověď buňky na stresové podmínky tím, že brání jejímu dělení a/nebo indukuje apoptózu. Mutace genu p53 byly nalezeny v téměř 50% lidských nádorů. Pro detekci a analýzu mutací p53 se používá několik přístupů: imunochemické metody detekuji hladinu proteinu p53, molekulární analýzy určují změny struktury DNA a funkční analýzy se zaměřují na biologické vlastnosti proteinu p53. Funkční analýza separovaných alel v kvasinkách určuje transaktivační schopnost proteinu p53 exprimovaného v kvasinkách. Tato metoda, která pro syntézu p53 metoda využívá mRNA izolovanou z buněk a tkání a amlifikovanou RT-PCR, představuje důležitý nástroj pro rozlišení různých funkčních typů mutací p53. Pochopení dopadu mutací p53 pro jeho funkci je důležitým předpokladem pro zavedení účinných protinádorových terapií. (cs)
Title
  • Funcitonal analysis of p53 tumor suppressor in yeast
  • Funcitonal analysis of p53 tumor suppressor in yeast (en)
  • Funkční analýza nádorového supresoru p53 v kvasinkách (cs)
skos:prefLabel
  • Funcitonal analysis of p53 tumor suppressor in yeast
  • Funcitonal analysis of p53 tumor suppressor in yeast (en)
  • Funkční analýza nádorového supresoru p53 v kvasinkách (cs)
skos:notation
  • RIV/00216224:14310/05:00013878!RIV08-MSM-14310___
http://linked.open.../vavai/riv/strany
  • 261-277
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 522209
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/05:00013878
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • tumor suppressor; p53 mutation; p53 activity; FASAY (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [79E9F7855493]
http://linked.open...i/riv/nazevZdroje
  • Differentiation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 73
http://linked.open...iv/tvurceVysledku
  • Koptíková, Jana
  • Šmarda, Jan
  • Šmardová, Jana
http://linked.open...n/vavai/riv/zamer
issn
  • 0301-4681
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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