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Description
| - Toxaphene (CAS No. 800-35-2) is a complex mixture of several hundred components, that was used worldwide primarily as an agricultural pesticide with insecticide effects in the second half of the 20th century. In vitro investigations of genotoxicity and mutagenicity of toxaphene were in literature generally described, but they provided somewhat equivocal results. We re-evaluated the technical toxaphene in two prokaryotic systems. The SOS Chromotest showed high sensitivity to toxaphene. Three highest concentrations (40, 20 and 10 mg/l) were clearly positive and the dose-response effect was evident. In the umuC assay at concentrations from 2.5 to 40.0 mg/l, a dose-dependent increase in genotoxic activity was observed, but these results were found to be insignificant. Genotoxicity of toxaphene and its photodegradation products was also examined in this study after UV irradiation (3-6-9 h) at concentrations from 7.5 to 60.0 mg/l.
- Toxaphene (CAS No. 800-35-2) is a complex mixture of several hundred components, that was used worldwide primarily as an agricultural pesticide with insecticide effects in the second half of the 20th century. In vitro investigations of genotoxicity and mutagenicity of toxaphene were in literature generally described, but they provided somewhat equivocal results. We re-evaluated the technical toxaphene in two prokaryotic systems. The SOS Chromotest showed high sensitivity to toxaphene. Three highest concentrations (40, 20 and 10 mg/l) were clearly positive and the dose-response effect was evident. In the umuC assay at concentrations from 2.5 to 40.0 mg/l, a dose-dependent increase in genotoxic activity was observed, but these results were found to be insignificant. Genotoxicity of toxaphene and its photodegradation products was also examined in this study after UV irradiation (3-6-9 h) at concentrations from 7.5 to 60.0 mg/l. (en)
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Title
| - Genotoxic activity of a technical toxaphene mixture and its photodegradation products in the SOS genotoxicity tests
- Genotoxic activity of a technical toxaphene mixture and its photodegradation products in the SOS genotoxicity tests (en)
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skos:prefLabel
| - Genotoxic activity of a technical toxaphene mixture and its photodegradation products in the SOS genotoxicity tests
- Genotoxic activity of a technical toxaphene mixture and its photodegradation products in the SOS genotoxicity tests (en)
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skos:notation
| - RIV/00216224:14310/05:00013140!RIV10-GA0-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/05:00013140
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Toxaphene; genotoxicity assays; SOS response; umuC test; photodegradation; UV-irradiation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Holoubek, Ivan
- Čupr, Pavel
- Bartoš, Tomáš
- Škarek, Michal
- Kosubová, Petra
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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