About: Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts

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About: Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A damage of programmed cell death pathways is a frequent event during malignant transformation. In this study, we analyzed programmed cell daeth (PCD) in v-myb-transformed BM2 and human U937 promonocytes induced by arsenic trioxide,cycloheximide and camtothecin. The presence of functional v-Myb protein pre-determined the BM2 cells to autophagic pathway of PCD in response to the DNA-damaging agents. The absence of transactivating v-Myb protein allowed activation of PCD pathway marked by mitochondrial membrane depolarization and resulting in necrosis. the fact that the antiapoptotic function of the Myb protein can be overcome by alternative PCD pathway suggests that understanding of molecular mechanisms of autophagy could improve therapy of cancer cells suffering from defective apoptosis. A damage of programmed cell death pathways is a frequent event during malignant transformation. In this study, we analyzed programmed cell daeth (PCD) in v-myb-transformed BM2 and human U937 promonocytes induced by arsenic trioxide,cycloheximide and camtothecin. The presence of functional v-Myb protein pre-determined the BM2 cells to autophagic pathway of PCD in response to the DNA-damaging agents. The absence of transactivating v-Myb protein allowed activation of PCD pathway marked by mitochondrial membrane depolarization and resulting in necrosis. the fact that the antiapoptotic function of the Myb protein can be overcome by alternative PCD pathway suggests that understanding of molecular mechanisms of autophagy could improve therapy of cancer cells suffering from defective apoptosis. (en)
Title	Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts (en)
skos:prefLabel	Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts (en)
skos:notation	RIV/00216224:14310/05:00012668!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/1055), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Horváth, Viktor Souček, Karel Šmarda, Jan Ondroušková, Eva
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	513423
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/05:00012668
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	v-Myb; apoptosis; autophagy; camptohecin (en)
http://linked.open.../riv/klicoveSlovo	apoptosis autophagy v-Myb camptohecin
http://linked.open...ontrolniKodProRIV	[E02C0C81DAB0]
http://linked.open...v/mistoKonaniAkce	Budapest, Hungary
http://linked.open...i/riv/mistoVydani	Budapest, Hungary
http://linked.open...i/riv/nazevZdroje	13th Euroconference on Apoptosis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Horváth, Viktor Souček, Karel Šmarda, Jan Ondroušková, Eva
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2005-10-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	European Cell Death Organization
https://schema.org/isbn	963-219-273-7
http://localhost/t...ganizacniJednotka	14310

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