About: CBP sensitizes v-myb-transformed monoblasts to differentiation inducers

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About: CBP sensitizes v-myb-transformed monoblasts to differentiation inducers Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CREB-binding protein (CBP) regulates gene expression by binding to certain components of basal transcription machinery and by histone acetylation. In addition, it integrates various cellular signaling pathways through binding to multiple transcription factors, including the Myb proteins. We report in this study that CBP can partially suppress function of the v-Myb oncoprotein in leukemic cells. Although originally described as activator of v-Myb function, we show that CBP can also act as v-Myb suppressor. Ectopic expression of murine CBP in v-Myb-transformed chicken monoblasts reduced transcriptional activation abilities of the v-Myb protein and increased sensitivity to differentiation inducers such as phorbol ester or trichostatin A. In addition, exogenous CBP affected morphology of differentiated cells derived from BM2 monoblasts. Altogether, these results indicate that cellular context is an important factor to determine whether CBP will activate or suppress the protein it targets. CREB-binding protein (CBP) regulates gene expression by binding to certain components of basal transcription machinery and by histone acetylation. In addition, it integrates various cellular signaling pathways through binding to multiple transcription factors, including the Myb proteins. We report in this study that CBP can partially suppress function of the v-Myb oncoprotein in leukemic cells. Although originally described as activator of v-Myb function, we show that CBP can also act as v-Myb suppressor. Ectopic expression of murine CBP in v-Myb-transformed chicken monoblasts reduced transcriptional activation abilities of the v-Myb protein and increased sensitivity to differentiation inducers such as phorbol ester or trichostatin A. In addition, exogenous CBP affected morphology of differentiated cells derived from BM2 monoblasts. Altogether, these results indicate that cellular context is an important factor to determine whether CBP will activate or suppress the protein it targets. (en)
Title	CBP sensitizes v-myb-transformed monoblasts to differentiation inducers CBP sensitizes v-myb-transformed monoblasts to differentiation inducers (en)
skos:prefLabel	CBP sensitizes v-myb-transformed monoblasts to differentiation inducers CBP sensitizes v-myb-transformed monoblasts to differentiation inducers (en)
skos:notation	RIV/00216224:14310/05:00012558!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/1055), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Navrátilová, Jarmila Šmarda, Jan Nemajerová, Alice Šmardová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	514554
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/05:00012558
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CBP; v-Myb; hematopoiesis; differentiation; monoblasts (en)
http://linked.open.../riv/klicoveSlovo	CBP hematopoiesis differentiation v-Myb monoblasts
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C2C617FA9FE6]
http://linked.open...i/riv/nazevZdroje	Differentiation
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Šmarda, Jan Nemajerová, Alice Šmardová, Jana Navrátilová, Jarmila Jurdic, Pierre
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0301-4681
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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