About: Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts

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About: Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In order to investigate the versatility of proteom of leukemic cells undergoing terminal differentiation, we performed two-dimensional electrophoresis of proteins extracted from BM2 cells induced with phorbol ester TPA, trichostatin A and retinoic acid for various time periods and compared it with two-dimensional electrophoretogram of untreated control cells. Some of the spots of differentially expressed proteins were digested with trypsin and identified by MALDI-TOF mass spectrometry as heat shock protein 70, protein-glutamine glutamyltransferase 4, prostaglandin-D-synthase, EMS1, nucleobindin 2 precursor (DNA-binding protein NEFA), actin, ARP2/3 protein complex subunit 3 and chaperonin Hsp60. Biological significance of versatility of these proteins in differentiating BM2 cells is currently investigated. In order to investigate the versatility of proteom of leukemic cells undergoing terminal differentiation, we performed two-dimensional electrophoresis of proteins extracted from BM2 cells induced with phorbol ester TPA, trichostatin A and retinoic acid for various time periods and compared it with two-dimensional electrophoretogram of untreated control cells. Some of the spots of differentially expressed proteins were digested with trypsin and identified by MALDI-TOF mass spectrometry as heat shock protein 70, protein-glutamine glutamyltransferase 4, prostaglandin-D-synthase, EMS1, nucleobindin 2 precursor (DNA-binding protein NEFA), actin, ARP2/3 protein complex subunit 3 and chaperonin Hsp60. Biological significance of versatility of these proteins in differentiating BM2 cells is currently investigated. (en)
Title	Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts (en)
skos:prefLabel	Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts (en)
skos:notation	RIV/00216224:14310/05:00012437!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/1055), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Černá, Karolína Váňa, Petr Zdráhal, Zbyněk Šmarda, Jan Ondroušková, Eva Konečná, Hana
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	548731
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/05:00012437
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Proteome; v-myb; differentiation; mass spectrometry; two-dimensional electrohoresis (en)
http://linked.open.../riv/klicoveSlovo	two-dimensional electrohoresis mass spectrometry Proteome differentiation v-myb
http://linked.open...ontrolniKodProRIV	[51E5553CC3CF]
http://linked.open...v/mistoKonaniAkce	Bratislava
http://linked.open...i/riv/mistoVydani	Bratislava
http://linked.open...i/riv/nazevZdroje	Študentská vedecká konferencia
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Konečná, Hana Zdráhal, Zbyněk Černá, Karolína Šmarda, Jan Ondroušková, Eva Váňa, Petr
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2005-04-19 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Univerzita Komenského v Bratislave
https://schema.org/isbn	80-88870-46-1
http://localhost/t...ganizacniJednotka	14310

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