About: The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo

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About: The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This in vivo study employs p27-deficient mice to investigate the significance of p27 for the metabolism of D-type cyclins in differentiated cells. The absence of p27 results in decreased levels of cyclins D2 and/or D3 in some organs. As demonstrated on Leydig cells of testis, such dependency is only restricted to certain cell types including terminally differentiated ones, and the absence of p27 in these cells can interfere with their differentiation. The decrease of cyclin D caused by the absence of p27 equals the amount of cyclin D physically associated with p27 in non-mutant animals. The data indicate that it is the proportion of p27-associated cyclin D that determines the response to p27 deficiency. Cells in which the level of D-type cyclin is dependent on p27 do not up-regulate the activity of their CDK2 and CDK4 upon loss of p27, and these cells have a negligible amount of p27 bound to CDK2 and/or cyclin A/E under normal conditions. This in vivo study employs p27-deficient mice to investigate the significance of p27 for the metabolism of D-type cyclins in differentiated cells. The absence of p27 results in decreased levels of cyclins D2 and/or D3 in some organs. As demonstrated on Leydig cells of testis, such dependency is only restricted to certain cell types including terminally differentiated ones, and the absence of p27 in these cells can interfere with their differentiation. The decrease of cyclin D caused by the absence of p27 equals the amount of cyclin D physically associated with p27 in non-mutant animals. The data indicate that it is the proportion of p27-associated cyclin D that determines the response to p27 deficiency. Cells in which the level of D-type cyclin is dependent on p27 do not up-regulate the activity of their CDK2 and CDK4 upon loss of p27, and these cells have a negligible amount of p27 bound to CDK2 and/or cyclin A/E under normal conditions. (en)
Title	The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo (en)
skos:prefLabel	The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo (en)
skos:notation	RIV/00216224:14310/04:00064402!RIV13-MSM-14310___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA204/01/0905), P(LN00A065), Z(AV0Z5039906), Z(MSM 432100001)
http://linked.open...iv/cisloPeriodika	2-3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Faldíková, Ludmila Bryja, Vítězslav Pacherník, Jiří Krejčí, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	584993
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/04:00064402
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	D-type cyclin; p27; differentiation; p27-deficient mouse; Leydig cell; thymus; lung (en)
http://linked.open.../riv/klicoveSlovo	thymus p27 differentiation lung D-type cyclin Leydig cell p27-deficient mouse
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[B84F1623BF9A]
http://linked.open...i/riv/nazevZdroje	Biochimica et biophysica acta : Molecular Cell Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair Interactions and functions of cell cycle regulators in cell differentiation
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	1691
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Dvořák, Petr Hampl, Aleš Krejčí, Pavel Pacherník, Jiří Faldíková, Ludmila Pogue, R. Nevriva, I
http://linked.open...ain/vavai/riv/wos	000221211800004
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20432100001 The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	0167-4889
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbamer.2004.01.001
http://localhost/t...ganizacniJednotka	14310

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