About: Imidazopyrazines as Cyclin Dependent Kinase Inhibitors     Goto   Sponge   NotDistinct   Permalink

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  • In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compds. of formula I [R = H, halo, (un)substituted-aryl, -heteroaryl, -cycloalkyl, etc.; R1 = H, halo or alkyl; R2 = halo, (un)substituted-alkyl, -aryl, -arylalkyl, etc.; R3 = H, (un)substituted-aryl, -heteroaryl, -heterocyclyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 8-chloro-3-methylimidazo[1,2-a]pyrazine with 4-(aminomethyl)pyridine. I possessed excellent CDK inhibitory properties, e.g., II demonstrated an IC50 value of 22.5 uM.
  • In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compds. of formula I [R = H, halo, (un)substituted-aryl, -heteroaryl, -cycloalkyl, etc.; R1 = H, halo or alkyl; R2 = halo, (un)substituted-alkyl, -aryl, -arylalkyl, etc.; R3 = H, (un)substituted-aryl, -heteroaryl, -heterocyclyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 8-chloro-3-methylimidazo[1,2-a]pyrazine with 4-(aminomethyl)pyridine. I possessed excellent CDK inhibitory properties, e.g., II demonstrated an IC50 value of 22.5 uM. (en)
Title
  • Imidazopyrazines as Cyclin Dependent Kinase Inhibitors
  • Imidazopyrazines as Cyclin Dependent Kinase Inhibitors (en)
skos:prefLabel
  • Imidazopyrazines as Cyclin Dependent Kinase Inhibitors
  • Imidazopyrazines as Cyclin Dependent Kinase Inhibitors (en)
skos:notation
  • RIV/00216224:14310/04:00035995!RIV10-MSM-14310___
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http://linked.open...avai/riv/aktivita
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  • N
http://linked.open...cisloPatentuVzoru
  • WO 2004026877 A1
http://linked.open...eleniPatentuVzoru
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  • 567311
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  • RIV/00216224:14310/04:00035995
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  • cyclin dependent kinase; inhibitor; imidazopyrazine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [A0C2A5C851DA]
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  • USA
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  • World Intellectual Property Organization
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  • Dwyer, Michael
  • Guzi, Timothy
  • Paruch, Kamil
  • Doll, Ronald
  • Mallams, Alan
  • Girivallabhan, Viyyoor
http://linked.open...mniOchranaPatentu
http://linked.open...avai/riv/vlastnik
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  • Schering-Plough
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  • 14310
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