About: Imidazopyridines as Cyclin Dependent Kinase Inhibitors

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compds. I [R = (un)substituted-alkyl, -aryl, -heteroaryl, -heterocyclyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -aryl, arylalkyl, alkenyl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was made by condensation of 8-amino-3-bromo-6-phenylimidazopyridine (prepn. given) with 5-formylpyrimidine. In inhibition assays with CDK2, I possessed excellent inhibitory properties, e.g., II possessed an IC50 value of 0.12 uM. In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compds. I [R = (un)substituted-alkyl, -aryl, -heteroaryl, -heterocyclyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -aryl, arylalkyl, alkenyl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was made by condensation of 8-amino-3-bromo-6-phenylimidazopyridine (prepn. given) with 5-formylpyrimidine. In inhibition assays with CDK2, I possessed excellent inhibitory properties, e.g., II possessed an IC50 value of 0.12 uM. (en)
Title	Imidazopyridines as Cyclin Dependent Kinase Inhibitors Imidazopyridines as Cyclin Dependent Kinase Inhibitors (en)
skos:prefLabel	Imidazopyridines as Cyclin Dependent Kinase Inhibitors Imidazopyridines as Cyclin Dependent Kinase Inhibitors (en)
skos:notation	RIV/00216224:14310/04:00035992!RIV10-MSM-14310___
http://linked.open...tracePatentuVzoru	2003-09-13 (xsd:date)
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...cisloPatentuVzoru	WO 2004/026867 A2
http://linked.open...eleniPatentuVzoru	2004-04-01 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Paruch, Kamil
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	567312
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/04:00035992
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cyclin dependent kinase; ínhibitors; pyrazolopyridine (en)
http://linked.open.../riv/klicoveSlovo	ínhibitors pyrazolopyridine cyclin dependent kinase
http://linked.open...ontrolniKodProRIV	[A6803A88E2E8]
http://linked.open.../licencniPoplatek	A - Poskytovatel licence na výsledek požaduje licenční poplatek
http://linked.open...ydaniPatentuVzoru	USA
http://linked.open...atelePatentuVzoru	World Intellectual Property Organization
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...ydaniPatentuVzoru	US - Spojené státy americké
http://linked.open...iv/tvurceVysledku	Dwyer, Michael Guzi, Timothy Paruch, Kamil Doll, Ronald Girijavallabhan, Viyyoor Keertikar, Kartik
http://linked.open...mniOchranaPatentu	B - USTPO (Úřad pro patenty a ochranné známky USA)
http://linked.open...avai/riv/vlastnik	Schering-Plough
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	A - Pouze udělený nebo využívaný pouze vlastníkem
http://linked.open...stnikPatentuVzoru	Schering-Plough
http://localhost/t...ganizacniJednotka	14310

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