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Description
| - The title compds. pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.
- The title compds. pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed. (en)
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Title
| - Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
- Pyrazolopyrimidines as cyclin-dependent kinase inhibitors (en)
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skos:prefLabel
| - Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
- Pyrazolopyrimidines as cyclin-dependent kinase inhibitors (en)
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skos:notation
| - RIV/00216224:14310/04:00035987!RIV10-MSM-14310___
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http://linked.open...tracePatentuVzoru
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/04:00035987
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cyclin dependent kinase; inhibitor; pyrazolopyrimidine (en)
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http://linked.open.../riv/klicoveSlovo
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| - United States Patent and Trademark Office
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http://linked.open...in/vavai/riv/obor
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http://linked.open...iv/tvurceVysledku
| - Alvarez, Carmen
- Dwyer, Michael
- Fischmann, Thierry
- Guzi, Timothy
- Madison, Vincent
- Paruch, Kamil
- Chan, Tin-Yau
- Doll, Ronald
- James, Ray
- Paradkar, Vidyadhar
- Park, Haengsoon
- Rivera, Jocelyn
- Girijavallabhan, Viyyoor
- Mallams, Alan
- Keertikar, Kartik
- Dillard, Lawrence
- Tran, Vinh
- Hobbs, Douglas
- Zhen, Min
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