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| Description
| - Programmed cell death (PCD) pathways are frequently damaged during processes of malignant transformation. Abrogation of PCD can significantly affect the response of the cancer cell to a therapy. Therefore, understanding of molecular mechanisms regulating PCD in cancer cells is of potential clinical interest. In this study we analyzed PCD pathways in the cells of two leukemia cell lines: human U937 promonocytes and chicken v-myb-transformed BM2 monoblasts. PCD of these cells was induced using three agents: arsenic trioxide induces PCD by elevation of the intracellular level of hydrogen peroxide, cycloheximide acts as inhibitor of proteosynthesis and camptothecin inhibits activity of DNA topoisomerase I thus causing DNA damage. We found the mechanisms of PCD activated in BM2 and U937 cells by these agents partially different. Under conditions when U937 cells undergo caspase-mediated apoptosis, BM2 cells die by caspase-independent pathway. In addition, DNA damage caused by camptothecin results in a switc
- Programmed cell death (PCD) pathways are frequently damaged during processes of malignant transformation. Abrogation of PCD can significantly affect the response of the cancer cell to a therapy. Therefore, understanding of molecular mechanisms regulating PCD in cancer cells is of potential clinical interest. In this study we analyzed PCD pathways in the cells of two leukemia cell lines: human U937 promonocytes and chicken v-myb-transformed BM2 monoblasts. PCD of these cells was induced using three agents: arsenic trioxide induces PCD by elevation of the intracellular level of hydrogen peroxide, cycloheximide acts as inhibitor of proteosynthesis and camptothecin inhibits activity of DNA topoisomerase I thus causing DNA damage. We found the mechanisms of PCD activated in BM2 and U937 cells by these agents partially different. Under conditions when U937 cells undergo caspase-mediated apoptosis, BM2 cells die by caspase-independent pathway. In addition, DNA damage caused by camptothecin results in a switc (en)
- V této práci jsme studovali dráhy programované buněčné smrti (PCD) v linii lidských promocytů (U937) a kuřecích monoblastů transformovaných v-myb (BM2). PCD těchto buněk byla idnukována třemi činidly: oxidem arsenitým, cykloheximidem a kamptotecinem. Zjistili jsme, že za podmínek, kdy buňky U937 odumírají apoptózou, buňky BM2 používají jinou dráhu PCD, která je nezávislá na kaspázách. Poškození DNA způsobené u buněk BM2 kamptotecinem, způsobuje autofagii. Naše výsledky dokazují onkoprotein v-Myb může být významně zapojen do procesů regulace PCD v leikemických bnkách. (cs)
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| Title
| - Camptothecin induces autophagy of v-myb-transformed monoblasts
- Camptothecin induces autophagy of v-myb-transformed monoblasts (en)
- Kamptotecin indukuje autofagii monoblastů transformovaných onkogenem v-myb (cs)
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| skos:prefLabel
| - Camptothecin induces autophagy of v-myb-transformed monoblasts
- Camptothecin induces autophagy of v-myb-transformed monoblasts (en)
- Kamptotecin indukuje autofagii monoblastů transformovaných onkogenem v-myb (cs)
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| skos:notation
| - RIV/00216224:14310/04:00019786!RIV08-MSM-14310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA301/03/1055), Z(MSM 143100008)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/04:00019786
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Myb; differentiation; programmed cell death; autophagy (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Horváth, Viktor
- Souček, Karel
- Šmarda, Jan
- Ondroušková, Eva
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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