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| rdf:type
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| Description
| - The aim of our work was to study of protonation/deprotonation equilibrium of AZT and AZU in aqueous solutions with different concentrations of NaCl by using UV spectra connected with chemometrics. Calibration and correct function of pH meter (electrode) was performed by acido-basic potenciometric titration (HCl and NaOH), of which parameters were calculated by means of GranLs method. Correct way how to determine ionization constants was verified using thymidine and uridine for which the pKa value was known. The absorption spectra were measured from 240 to 320 nm at temperature 25C and various ionic strength from 0.05M to 0.25M. The absorption maxima of thymidine and AZT are very close and have values of 267 and 266.5 nm for pH 8, respectively. The wavelength of maxima of uridine and AZU were identical 262nm, but the absorbance of AZU has hypochromical shift. Firstly, from non-smoothed spectra the system of matrices (É, A.U., pH) was made (Fig. a), that were the input data for Multivariate Curve Resolu
- The aim of our work was to study of protonation/deprotonation equilibrium of AZT and AZU in aqueous solutions with different concentrations of NaCl by using UV spectra connected with chemometrics. Calibration and correct function of pH meter (electrode) was performed by acido-basic potenciometric titration (HCl and NaOH), of which parameters were calculated by means of GranLs method. Correct way how to determine ionization constants was verified using thymidine and uridine for which the pKa value was known. The absorption spectra were measured from 240 to 320 nm at temperature 25C and various ionic strength from 0.05M to 0.25M. The absorption maxima of thymidine and AZT are very close and have values of 267 and 266.5 nm for pH 8, respectively. The wavelength of maxima of uridine and AZU were identical 262nm, but the absorbance of AZU has hypochromical shift. Firstly, from non-smoothed spectra the system of matrices (É, A.U., pH) was made (Fig. a), that were the input data for Multivariate Curve Resolu (en)
- Usilím naší práce bylo získat pK hodnoty u thymidinu a azidothymidinu z vodných roztoků změřených pomocí UV spektroskopie.K vyhodnocování spekter thymidinu a azidothymidinu bylo použito chemometrické metody; Multivariate Curve Resolution MCR. (cs)
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| Title
| - The protonation/deprotonation equilibrium of thymidine and azidothymidine studied by UV spectra and multivariate curve resolution
- The protonation/deprotonation equilibrium of thymidine and azidothymidine studied by UV spectra and multivariate curve resolution (en)
- Protonaní/deprotonaní rovnováhy thymidinu a azidothymidinu studované pomocí UV spektrometrie a chemometrie (cs)
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| skos:prefLabel
| - The protonation/deprotonation equilibrium of thymidine and azidothymidine studied by UV spectra and multivariate curve resolution
- The protonation/deprotonation equilibrium of thymidine and azidothymidine studied by UV spectra and multivariate curve resolution (en)
- Protonaní/deprotonaní rovnováhy thymidinu a azidothymidinu studované pomocí UV spektrometrie a chemometrie (cs)
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| skos:notation
| - RIV/00216224:14310/04:00011238!RIV08-AV0-14310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA203/02/0422), P(IAA1163201)
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/04:00011238
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Thymidine; Azidothymidine; UV spectra; Multivariate Curve Resolution (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - sborník- XLVII Zjazd PTchem i SITPChem Wroclaw 2004
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Trnková, Libuše
- Topinková, Jana
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - Polskie Towarystwo Chemiczne
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| http://localhost/t...ganizacniJednotka
| |
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