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| Description
| - Square wave a eliminační voltametrická analýza azidothymidinu v přítomnosti oligonukleotidů a chromosomální DNA (cs)
- Azidothymidine (AZT, 3-azido-3-deoxythymidine, Zidovudine, Retrovir) is an approved and widely used antiretroviral drug for the treatment of human immunodeficiency virus (HIV) infection. Dynamic electrochemical methods, have been employed for the fast and inexpensive determination of this drug in natural samples. The electrochemical signal of AZT, resulting from the reduction of azido group, was studied by square wave voltammetry (SWV), linear sweep voltammetry (LSV) and elimination voltammetry with linear scan (EVLS) using a hanging mercury drop electrode (HMDE). This paper explores the possibility of determining AZT in the presence of native (dsDNA) or denatured calf thymus DNA (ssDNA), and/or some synthetic oligodeoxynucleotides (ODNs). The detection limit of AZT in the absence and in the presence of ssDNA (10 mg/mL) is 1 nM and 250 nM, respectively. It was found that the signal of AZT is not substantially affected by the presence of DNA. We can therefore assume that the electrons are transferred t
- Azidothymidine (AZT, 3-azido-3-deoxythymidine, Zidovudine, Retrovir) is an approved and widely used antiretroviral drug for the treatment of human immunodeficiency virus (HIV) infection. Dynamic electrochemical methods, have been employed for the fast and inexpensive determination of this drug in natural samples. The electrochemical signal of AZT, resulting from the reduction of azido group, was studied by square wave voltammetry (SWV), linear sweep voltammetry (LSV) and elimination voltammetry with linear scan (EVLS) using a hanging mercury drop electrode (HMDE). This paper explores the possibility of determining AZT in the presence of native (dsDNA) or denatured calf thymus DNA (ssDNA), and/or some synthetic oligodeoxynucleotides (ODNs). The detection limit of AZT in the absence and in the presence of ssDNA (10 mg/mL) is 1 nM and 250 nM, respectively. It was found that the signal of AZT is not substantially affected by the presence of DNA. We can therefore assume that the electrons are transferred t (en)
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| Title
| - Square wave a eliminační voltametrická analýza azidothymidinu v přítomnosti oligonukleotidů a chromosomální DNA (cs)
- Square wave and elimination voltammetric analysis of azidothymidine in the presence of oligonucleotides and chromosomal DNA
- Square wave and elimination voltammetric analysis of azidothymidine in the presence of oligonucleotides and chromosomal DNA (en)
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| skos:prefLabel
| - Square wave a eliminační voltametrická analýza azidothymidinu v přítomnosti oligonukleotidů a chromosomální DNA (cs)
- Square wave and elimination voltammetric analysis of azidothymidine in the presence of oligonucleotides and chromosomal DNA
- Square wave and elimination voltammetric analysis of azidothymidine in the presence of oligonucleotides and chromosomal DNA (en)
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| skos:notation
| - RIV/00216224:14310/04:00011180!RIV08-AV0-14310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA203/02/0422), P(IAA1163201)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/04:00011180
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Azidothymidine (AZT); Square wave voltammetry (SWV); Linear sweep voltammetry (LSV); Elimination voltammetry with linear scan (EVLS); Hanging mercury drop electrode (HMDE); oligonucleotides; PCR product; chromosomal DNA (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kizek, René
- Trnková, Libuše
- Vacek, Jan
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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