About: Electroanalytical determination of d(GCGAAGC) hairpin

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Elektroktroanalytické stanovení oligonukleotidu d(GCGAAGC) (cs) Hairpins (or hairpin-like structures) may play a major role in expansion events of triplet repeat expansion diseases (X syndrome, Huntington s disease, Friedreich s ataxia). The d(GCGAAGC) fragment has been found in the replication origins of phage fX 174 and herpes simplex virus, in a promoter region of an E.coli heat-shock gene, and in rRNA genes. The paper deals with the application of electrochemical methods to the determination of the DNA heptamer - d(GCGAAGC) which forms very stable hairpin structure in aqueous solutions. On mercury electrodes this hairpin provides voltammetric reduction signals of adenine and cytosine, and oxidation signals of guanine. Both signals have been studied by cyclic voltammetry (CV), linear sweep voltammetry (LSV), and elimination voltammetry with linear scan (EVLS) in dependence on pH, accumulation time, scan rate, and loop sequences. The EVLS in combination with the adsorptive stripping was employed to the determination of the detection limit (LD) of this mini-hairp Hairpins (or hairpin-like structures) may play a major role in expansion events of triplet repeat expansion diseases (X syndrome, Huntington s disease, Friedreich s ataxia). The d(GCGAAGC) fragment has been found in the replication origins of phage fX 174 and herpes simplex virus, in a promoter region of an E.coli heat-shock gene, and in rRNA genes. The paper deals with the application of electrochemical methods to the determination of the DNA heptamer - d(GCGAAGC) which forms very stable hairpin structure in aqueous solutions. On mercury electrodes this hairpin provides voltammetric reduction signals of adenine and cytosine, and oxidation signals of guanine. Both signals have been studied by cyclic voltammetry (CV), linear sweep voltammetry (LSV), and elimination voltammetry with linear scan (EVLS) in dependence on pH, accumulation time, scan rate, and loop sequences. The EVLS in combination with the adsorptive stripping was employed to the determination of the detection limit (LD) of this mini-hairp (en)
Title	Elektroktroanalytické stanovení oligonukleotidu d(GCGAAGC) (cs) Electroanalytical determination of d(GCGAAGC) hairpin Electroanalytical determination of d(GCGAAGC) hairpin (en)
skos:prefLabel	Elektroktroanalytické stanovení oligonukleotidu d(GCGAAGC) (cs) Electroanalytical determination of d(GCGAAGC) hairpin Electroanalytical determination of d(GCGAAGC) hairpin (en)
skos:notation	RIV/00216224:14310/04:00011178!RIV08-AV0-14310___
http://linked.open.../vavai/riv/strany	25-30
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA203/02/0422), P(IAA1163201)
http://linked.open...iv/cisloPeriodika	63
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Trnková, Libuše Holík, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	562494
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/04:00011178
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	The DNA heptamer d(GCGAAGC); mini-hairpins; Linear sweep voltammetry (LSV); Cyclic voltammetry (CV); Elimination voltammetry with linear scan (EVLS); Hanging mercury drop electrode (HMDE); adsorptive stripping procedure (en)
http://linked.open.../riv/klicoveSlovo	Elimination voltammetry with linear scan (EVLS) Linear sweep voltammetry (LSV) adsorptive stripping procedure Hanging mercury drop electrode (HMDE) The DNA heptamer d(GCGAAGC) mini-hairpins Cyclic voltammetry (CV)
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[115864FD27A5]
http://linked.open...i/riv/nazevZdroje	Bioelectrochemistry
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New trends in electrochemistry of nucleic acids and their applications in enviromental chemistry Application of adsorptive transfer and elemination techniques in oligonucleotides and nucleic acids analysis.
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	2004
http://linked.open...iv/tvurceVysledku	Trnková, Libuše Postbieglová, Irena Holík, Miroslav
issn	1567-5394
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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