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| Description
| - Molecular dynamics (MD) simulations of Kink-turn (K-turn) RNA motifs reveal hinge-like motions on the nano-second (ns) timescale. K-turn motifs are asymmetric internal loops found at conserved positions in the 16S and 23S ribosomal RNAs, and characterized by sharp bends in both phosphodiester backbones producing V-shaped structures. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent MD simulations for selected K-turn motifs from 23S ribosomal RNA, Kt-38 (located at the base of the A-site finger), Kt-42 (located at the base of the L7/L12 stalk in the factor-binding site) and Kt-58 (located in Domain III). On a nano-second timescale, K-turns sample isoenergetic conformational substates. The simulations reveal the presence of long-residency sites for water, one of which is located close to the sharp turn of the phosphodiester backbones and, when occupied, mediates minor-groove interactions between the st
- Molecular dynamics (MD) simulations of Kink-turn (K-turn) RNA motifs reveal hinge-like motions on the nano-second (ns) timescale. K-turn motifs are asymmetric internal loops found at conserved positions in the 16S and 23S ribosomal RNAs, and characterized by sharp bends in both phosphodiester backbones producing V-shaped structures. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent MD simulations for selected K-turn motifs from 23S ribosomal RNA, Kt-38 (located at the base of the A-site finger), Kt-42 (located at the base of the L7/L12 stalk in the factor-binding site) and Kt-58 (located in Domain III). On a nano-second timescale, K-turns sample isoenergetic conformational substates. The simulations reveal the presence of long-residency sites for water, one of which is located close to the sharp turn of the phosphodiester backbones and, when occupied, mediates minor-groove interactions between the st (en)
- Molecular dynamics (MD) simulations of Kink-turn (K-turn) RNA motifs reveal hinge-like motions on the nano-second (ns) timescale. K-turn motifs are asymmetric internal loops found at conserved positions in the 16S and 23S ribosomal RNAs, and characterized by sharp bends in both phosphodiester backbones producing V-shaped structures. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent MD simulations for selected K-turn motifs from 23S ribosomal RNA, Kt-38 (located at the base of the A-site finger), Kt-42 (located at the base of the L7/L12 stalk in the factor-binding site) and Kt-58 (located in Domain III). On a nano-second timescale, K-turns sample isoenergetic conformational substates. The simulations reveal the presence of long-residency sites for water, one of which is located close to the sharp turn of the phosphodiester backbones and, when occupied, mediates minor-groove interactions between the st (cs)
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| Title
| - Hinge-like motions in RNA kink-turn motifs
- Hinge-like motions in RNA kink-turn motifs (en)
- Pantove pohyby RNA Kink-turn motivov (cs)
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| skos:prefLabel
| - Hinge-like motions in RNA kink-turn motifs
- Hinge-like motions in RNA kink-turn motifs (en)
- Pantove pohyby RNA Kink-turn motivov (cs)
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| skos:notation
| - RIV/00216224:14310/04:00010307!RIV08-MSM-14310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/04:00010307
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Modelling and Design of Molecular Materials, Program-Book of Abstract
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Koča, Jaroslav
- Rázga, Filip
- Šponer, Jiří
- Leontis, Neocles B.
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
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| http://localhost/t...ganizacniJednotka
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