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| rdf:type
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| Description
| - Hinge-like RNA motifs called kink-turns occur at conserved positions in the 16S and 23S ribosomal RNAs.The presence of K-turns at key functional sites in the ribosome suggests that they confer flexibility to RNA protuberances that regulate the traversal of tRNAs from one binding site to another across the interface between the small and large subunit during protein synthesis cycle. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs. The simulations indicate that K-turns are dynamically flexible, and thus capable of regulating significant inter-segmental motions. The simulations reveal specific long-residency hydration sites and monovalent counterions that stabilize non-Watson-Crick basepairs, sharp turns of the phosphodiester backbone and even mediate inter-segmental contacts. The implications for ribosome function will be discussed.
- Hinge-like RNA motifs called kink-turns occur at conserved positions in the 16S and 23S ribosomal RNAs.The presence of K-turns at key functional sites in the ribosome suggests that they confer flexibility to RNA protuberances that regulate the traversal of tRNAs from one binding site to another across the interface between the small and large subunit during protein synthesis cycle. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs. The simulations indicate that K-turns are dynamically flexible, and thus capable of regulating significant inter-segmental motions. The simulations reveal specific long-residency hydration sites and monovalent counterions that stabilize non-Watson-Crick basepairs, sharp turns of the phosphodiester backbone and even mediate inter-segmental contacts. The implications for ribosome function will be discussed. (en)
- Hinge-like RNA motifs called kink-turns occur at conserved positions in the 16S and 23S ribosomal RNAs.The presence of K-turns at key functional sites in the ribosome suggests that they confer flexibility to RNA protuberances that regulate the traversal of tRNAs from one binding site to another across the interface between the small and large subunit during protein synthesis cycle. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs. The simulations indicate that K-turns are dynamically flexible, and thus capable of regulating significant inter-segmental motions. The simulations reveal specific long-residency hydration sites and monovalent counterions that stabilize non-Watson-Crick basepairs, sharp turns of the phosphodiester backbone and even mediate inter-segmental contacts. The implications for ribosome function will be discussed. (cs)
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| Title
| - Dynamika RNA Kink-turnov: uloha molekul vody (cs)
- Dynamics of RNA Kink-turns: Role of water molecules
- Dynamics of RNA Kink-turns: Role of water molecules (en)
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| skos:prefLabel
| - Dynamika RNA Kink-turnov: uloha molekul vody (cs)
- Dynamics of RNA Kink-turns: Role of water molecules
- Dynamics of RNA Kink-turns: Role of water molecules (en)
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| skos:notation
| - RIV/00216224:14310/04:00010007!RIV08-MSM-14310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/04:00010007
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - RNA; water; modeling (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - American Chemical Society Division of Computers in Chemistry - Abstracts
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Koča, Jaroslav
- Rázga, Filip
- Šponer, Jiří
- Leontis, Neocles B.
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - American Chemical Society
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| http://localhost/t...ganizacniJednotka
| |
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