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| rdf:type
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| Description
| - Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA
- Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA (en)
- Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA (cs)
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| Title
| - Dynamika flexibilnych RNA pantov dolezitych pre funkciu ribozomu: ne-Watson-Crick-ovske pary bazi, modularna vystavba a specificka hydratacia RNA Kink-turn motivov (cs)
- Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns
- Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns (en)
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| skos:prefLabel
| - Dynamika flexibilnych RNA pantov dolezitych pre funkciu ribozomu: ne-Watson-Crick-ovske pary bazi, modularna vystavba a specificka hydratacia RNA Kink-turn motivov (cs)
- Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns
- Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns (en)
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| skos:notation
| - RIV/00216224:14310/04:00009958!RIV/2005/MSM/143105/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/04:00009958
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Molecular dynamics, RNA flexibility, non-Watson-Crick basepair, modular building, long-residency hydration (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
| - Academic and University Center, Nové Hrady
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Materials Structure in Chemistry, Biology, Physics and Technology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Koča, Jaroslav
- Rázga, Filip
- Réblová, Kamila
- Šponer, Jiří
- Leontis, Neocles B.
- Špačková, Naděžda
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| issn
| |
| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - Krystalografická společnost
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| http://localhost/t...ganizacniJednotka
| |
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