About: Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells

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About: Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Histone acetylation plays an important role in regulation of transcription and is particularlry relevant to the regulation and pathology of hematopoiesis. In the present study, we examined the contribution of elevated histone acetylation to the differentiation of BM2 monoblasts. Inhibition of the activity of endogenous histone deacetylases by trichostatin A (TSA) resulted in histone hyperacetylation causing cell cycle arrest and differentiation of BM2 cells into macrophage polykaryons. TSA did not affect the level of v-Myb protein in BM2 cells, but it downregulated its transcription activation capability. This suggests that chromatin remodeling can be significantly engaged in regulation of proliferation and differentiation of leukemic cells. Histone acetylation plays an important role in regulation of transcription and is particularlry relevant to the regulation and pathology of hematopoiesis. In the present study, we examined the contribution of elevated histone acetylation to the differentiation of BM2 monoblasts. Inhibition of the activity of endogenous histone deacetylases by trichostatin A (TSA) resulted in histone hyperacetylation causing cell cycle arrest and differentiation of BM2 cells into macrophage polykaryons. TSA did not affect the level of v-Myb protein in BM2 cells, but it downregulated its transcription activation capability. This suggests that chromatin remodeling can be significantly engaged in regulation of proliferation and differentiation of leukemic cells. (en) Histone acetylation plays an important role in regulation of transcription and is particularlry relevant to the regulation and pathology of hematopoiesis. In the present study, we examined the contribution of elevated histone acetylation to the differentiation of BM2 monoblasts. Inhibition of the activity of endogenous histone deacetylases by trichostatin A (TSA) resulted in histone hyperacetylation causing cell cycle arrest and differentiation of BM2 cells into macrophage polykaryons. TSA did not affect the level of v-Myb protein in BM2 cells, but it downregulated its transcription activation capability. This suggests that chromatin remodeling can be significantly engaged in regulation of proliferation and differentiation of leukemic cells. (cs)
Title	Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells (en) Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells (cs)
skos:prefLabel	Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells (en) Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells (cs)
skos:notation	RIV/00216224:14310/03:00008979!RIV09-MSM-14310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 143100008)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Souček, Karel Šmarda, Jan Kubala, Lukáš Nemajerová, Alice Šmardová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	631574
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/03:00008979
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	myb; histone acetylation; trichostatin A; cyclin D (en)
http://linked.open.../riv/klicoveSlovo	histone acetylation cyclin D trichostatin A myb
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[95C24C8B1394]
http://linked.open...i/riv/nazevZdroje	Journal of Hematotherapy Stem Cell Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Kubala, Lukáš Souček, Karel Šmarda, Jan Nemajerová, Alice Šmardová, Jana Jurdic, Pierre
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143100008
issn	1061-6128
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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