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| rdf:type
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| Description
| - The structural, dynamical, and functional importance of water molecules for biomolecular structure and recognition is well-known. Water contributes significantly to the stability of biomacromolecules and plays a crucial role in molecular association. In general, buried water molecule is believed to be involved in local structural stabilization in proteins and DNA. These water molecules are critical for the binding affinity or specificity of protein-ligand complexes. It is important in the design of new ligands. X-ray crystallography, NMR spectroscopy, and neutron diffraction are typical experimental methods to analyze presence of water molecules at atomic level. However, high-resolution structures (better than 1.5 A) are preferred for reliable analysis of structural aspects of water molecules associated with host protein. In absence of high-resolution experimental data, theoretical studies, such as molecular dynamics simulations, represent complementary methods to locate water positions and understand
- The structural, dynamical, and functional importance of water molecules for biomolecular structure and recognition is well-known. Water contributes significantly to the stability of biomacromolecules and plays a crucial role in molecular association. In general, buried water molecule is believed to be involved in local structural stabilization in proteins and DNA. These water molecules are critical for the binding affinity or specificity of protein-ligand complexes. It is important in the design of new ligands. X-ray crystallography, NMR spectroscopy, and neutron diffraction are typical experimental methods to analyze presence of water molecules at atomic level. However, high-resolution structures (better than 1.5 A) are preferred for reliable analysis of structural aspects of water molecules associated with host protein. In absence of high-resolution experimental data, theoretical studies, such as molecular dynamics simulations, represent complementary methods to locate water positions and understand (en)
- The structural, dynamical, and functional importance of water molecules for biomolecular structure and recognition is well-known. Water contributes significantly to the stability of biomacromolecules and plays a crucial role in molecular association. In general, buried water molecule is believed to be involved in local structural stabilization in proteins and DNA. These water molecules are critical for the binding affinity or specificity of protein-ligand complexes. It is important in the design of new ligands. X-ray crystallography, NMR spectroscopy, and neutron diffraction are typical experimental methods to analyze presence of water molecules at atomic level. However, high-resolution structures (better than 1.5 A) are preferred for reliable analysis of structural aspects of water molecules associated with host protein. In absence of high-resolution experimental data, theoretical studies, such as molecular dynamics simulations, represent complementary methods to locate water positions and understand (cs)
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| Title
| - Hydration of the CDK2 active site. Molecular dynamics study. (en)
- Hydratace aktivniho mista enzymu CDK2. Studium pomoci molekulove dynamiky.
- Hydratace aktivniho mista enzymu CDK2. Studium pomoci molekulove dynamiky. (cs)
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| skos:prefLabel
| - Hydration of the CDK2 active site. Molecular dynamics study. (en)
- Hydratace aktivniho mista enzymu CDK2. Studium pomoci molekulove dynamiky.
- Hydratace aktivniho mista enzymu CDK2. Studium pomoci molekulove dynamiky. (cs)
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| skos:notation
| - RIV/00216224:14310/02:00007231!RIV08-MSM-14310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/02:00007231
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - CDK2; Molecular dynamics; Hydration; ATP (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Koča, Jaroslav
- Otyepka, Michal
- Kříž, Zdeněk
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - 54. Sjezd chemickych spolecnosti
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| http://localhost/t...ganizacniJednotka
| |
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