About: Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts     Goto   Sponge   NotDistinct   Permalink

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Description
  • BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells.
  • BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells. (en)
  • BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells. (cs)
Title
  • Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts
  • Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts (en)
  • Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts (cs)
skos:prefLabel
  • Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts
  • Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts (en)
  • Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts (cs)
skos:notation
  • RIV/00216224:14310/02:00006911!RIV08-MSM-14310___
http://linked.open.../vavai/riv/strany
  • 95
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 143100008)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 662700
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/02:00006911
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • p53; Myb; differentiation; proliferation; roscovitine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [1AB587C8FA7D]
http://linked.open...v/mistoKonaniAkce
  • 9.-11.9 2002, České Budějovice
http://linked.open...i/riv/mistoVydani
  • České Budějovice
http://linked.open...i/riv/nazevZdroje
  • Cells IV
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Šmarda, Jan
  • Ševčíková, Sabina
  • Navrátilová, Jarmila
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Kopp Publishing
https://schema.org/isbn
  • 80-7232-181-1
http://localhost/t...ganizacniJednotka
  • 14310
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