About: Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha

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About: Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tumor necrosis factor-a (TNF) is a pleiotropic cytokine. Besides other effects it promotes differentiation of leukaemic cells and activates (phosphorylates) jun-NH2-terminal kinase (JNK). JNK activation might be involved in signalling pathway leading to differentiation. MK-886 alone did not cause differentiation, however it increased non-specific esterase activity, reactive oxygen intermediates production and CD11b/CD14 cell surface antigen expression after TNF treatment, i. e. it potentiated differentiation of HL-60 cells. On the other hand indomethacin alone or in combination with TNF did not influence measured parameters of differentiation. Neither indomethacin, nor MK-886 influenced JNK activation. We concluded that endogenous LOX metabolites might play negative role in differentiation induced by TNF and that this effect is independent of JNK activation. These results may be beneficial for leukaemic patients. Tumor necrosis factor-a (TNF) is a pleiotropic cytokine. Besides other effects it promotes differentiation of leukaemic cells and activates (phosphorylates) jun-NH2-terminal kinase (JNK). JNK activation might be involved in signalling pathway leading to differentiation. MK-886 alone did not cause differentiation, however it increased non-specific esterase activity, reactive oxygen intermediates production and CD11b/CD14 cell surface antigen expression after TNF treatment, i. e. it potentiated differentiation of HL-60 cells. On the other hand indomethacin alone or in combination with TNF did not influence measured parameters of differentiation. Neither indomethacin, nor MK-886 influenced JNK activation. We concluded that endogenous LOX metabolites might play negative role in differentiation induced by TNF and that this effect is independent of JNK activation. These results may be beneficial for leukaemic patients. (en)
Title	Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha (en)
skos:prefLabel	Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha (en)
skos:notation	RIV/00216224:14310/01:00005223!RIV/2002/MSM/143102/N
http://linked.open.../vavai/riv/strany	68
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 143100008)
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Štika, Jiří Hofmanová, Jiřina Šimek, Vladimír
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	685386
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/01:00005223
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha (en)
http://linked.open.../riv/klicoveSlovo	Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha
http://linked.open...ontrolniKodProRIV	[3585AA062281]
http://linked.open...v/mistoKonaniAkce	Lvov
http://linked.open...i/riv/mistoVydani	Lvov
http://linked.open...i/riv/nazevZdroje	2nd International Scientific Conference
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
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http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Štika, Jiří Šimek, Vladimír
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2001-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143100008
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Univesity of Lviv, ukraine
http://localhost/t...ganizacniJednotka	14310

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