About: v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts     Goto   Sponge   NotDistinct   Permalink

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Description
  • The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells to mature blood cells. To gain insights into the role of fos/jun in leukemogenicity, we expressed v-fos and v-jun in the line of chicken monoblasts BM2. We found that either v-fos or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. This suggests that oncogenic forms of Jun adn Fos proteins can further enforce v-Myb transformation.
  • The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells to mature blood cells. To gain insights into the role of fos/jun in leukemogenicity, we expressed v-fos and v-jun in the line of chicken monoblasts BM2. We found that either v-fos or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. This suggests that oncogenic forms of Jun adn Fos proteins can further enforce v-Myb transformation. (en)
  • The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells to mature blood cells. To gain insights into the role of fos/jun in leukemogenicity, we expressed v-fos and v-jun in the line of chicken monoblasts BM2. We found that either v-fos or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. This suggests that oncogenic forms of Jun adn Fos proteins can further enforce v-Myb transformation. (cs)
Title
  • v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts
  • v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts (en)
  • v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts (cs)
skos:prefLabel
  • v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts
  • v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts (en)
  • v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts (cs)
skos:notation
  • RIV/00216224:14310/01:00004455!RIV09-GA0-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/01/0040), Z(MSM 143100008)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 700387
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/01:00004455
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Fos (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [C7E2A687C596]
http://linked.open...v/mistoKonaniAkce
  • June 20-23, 2001, Frederock, MD, USA
http://linked.open...i/riv/mistoVydani
  • Frederick, MD, USA
http://linked.open...i/riv/nazevZdroje
  • The 17th annual meeting on oncogenes
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Souček, Karel
  • Šmarda, Jan
  • Ševčíková, Sabina
  • Ondroušková, Eva
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Foundation for Advanced Cancer Studies, Inc.
http://localhost/t...ganizacniJednotka
  • 14310
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