About: Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26     Goto   Sponge   NotDistinct   Permalink

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Description
  • The haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (LinB) is the enzyme involved in the degradation ofthe important environmental pollutant g-hexachlorocyclohexane. The enzyme hydrolyzes a broad range of halogenated cyclic and aliphatic compounds. Here, we present the 1.58 A crystal structure of LinB and the 2.0 A structure of LinB with 1,3-propanediol, a product of debromination of 1,3-dibromopropane, in the active site of the enzyme. The enzyme belongs to the a/b-hydrolase family and contains a catalytic triad (Aspl08, His272, and Glu132) in the lipase-like topological arrangement previously proposed from mutagenesis experiments. The LinB structure was compared with the structures of haloalkane dehalogenase from Xanthobacter autotrophicus GJl0 and from Rhodococcus sp. and the structural features involved in the adaptation toward xenobiotic substrates were identified. The arrangement and composition of the a-helices in the cap domain results in the dif ferences in the size and shape of t
  • The haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (LinB) is the enzyme involved in the degradation ofthe important environmental pollutant g-hexachlorocyclohexane. The enzyme hydrolyzes a broad range of halogenated cyclic and aliphatic compounds. Here, we present the 1.58 A crystal structure of LinB and the 2.0 A structure of LinB with 1,3-propanediol, a product of debromination of 1,3-dibromopropane, in the active site of the enzyme. The enzyme belongs to the a/b-hydrolase family and contains a catalytic triad (Aspl08, His272, and Glu132) in the lipase-like topological arrangement previously proposed from mutagenesis experiments. The LinB structure was compared with the structures of haloalkane dehalogenase from Xanthobacter autotrophicus GJl0 and from Rhodococcus sp. and the structural features involved in the adaptation toward xenobiotic substrates were identified. The arrangement and composition of the a-helices in the cap domain results in the dif ferences in the size and shape of t (en)
Title
  • Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26
  • Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (en)
skos:prefLabel
  • Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26
  • Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (en)
skos:notation
  • RIV/00216224:14310/00:00002430!RIV/2002/MSM/143102/N
http://linked.open.../vavai/riv/strany
  • 14082
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 143100005)
http://linked.open...iv/cisloPeriodika
  • 46
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 707768
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/00:00002430
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [EB56FCF3580A]
http://linked.open...i/riv/nazevZdroje
  • Biochemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 39
http://linked.open...iv/tvurceVysledku
  • Damborský, Jiří
  • Kutá-Smatanová, Ivana
  • Marek, Jaromír
  • Nagata, Y.
  • Vévodová, Jitka
  • Svensson, L. A.
  • Takagi, M.
  • Newman, J.
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-2960
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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