About: Impact of cannabinoid receptor ligands on sensitization to methamphetamine effects on rat locomotor behaviour     Goto   Sponge   NotDistinct   Permalink

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  • Investigation in rats brought very resembling results described earlier in mice. However, there were registered at least some interspecies differences in the rat susceptibility to development of sensitization to methamphetamine effects. Comparing to mice it was more demanding to titrate a dose of methamphetamine producing behavioural sensitization. Furthermore we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we did not demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment with cannabinoid CB1 receptor antagonist AM 251 and methamphetamine. Finally, unlike the mice there was registered an alternative behavioural change after repeated methamphetamine treatment instead, the occurrence of stereotypic behaviour (nose rubbing).
  • Investigation in rats brought very resembling results described earlier in mice. However, there were registered at least some interspecies differences in the rat susceptibility to development of sensitization to methamphetamine effects. Comparing to mice it was more demanding to titrate a dose of methamphetamine producing behavioural sensitization. Furthermore we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we did not demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment with cannabinoid CB1 receptor antagonist AM 251 and methamphetamine. Finally, unlike the mice there was registered an alternative behavioural change after repeated methamphetamine treatment instead, the occurrence of stereotypic behaviour (nose rubbing). (en)
Title
  • Impact of cannabinoid receptor ligands on sensitization to methamphetamine effects on rat locomotor behaviour
  • Impact of cannabinoid receptor ligands on sensitization to methamphetamine effects on rat locomotor behaviour (en)
skos:prefLabel
  • Impact of cannabinoid receptor ligands on sensitization to methamphetamine effects on rat locomotor behaviour
  • Impact of cannabinoid receptor ligands on sensitization to methamphetamine effects on rat locomotor behaviour (en)
skos:notation
  • RIV/00216224:14210/08:00026170!RIV10-MSM-14210___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 371467
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14210/08:00026170
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • behavioural sensitization; methamphetamine; cannabinoids; open field test; rats (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [445A98810129]
http://linked.open...i/riv/nazevZdroje
  • Acta Veterinaria Brno
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 77
http://linked.open...iv/tvurceVysledku
  • Landa, Leoš
  • Šulcová, Alexandra
  • Šlais, Karel
http://linked.open...ain/vavai/riv/wos
  • 000257226400005
http://linked.open...n/vavai/riv/zamer
issn
  • 0001-7213
number of pages
http://localhost/t...ganizacniJednotka
  • 14210
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