About: Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes.     Goto   Sponge   NotDistinct   Permalink

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  • Propafenone, a class I antiarrhythmic agent, inhibits several membrane currents, however, its effect on ATP-sensitive potassium current (IKATP) of cerdiac cells have not been tested. We evaluated the blocking effect of 0.1 to 100 uM propafenone on the whole cell IKATP as triggered by dinitrophenol in aduld rabbit isolated atrial and ventricular cardiomyocytes. It is concluded that propafenone blocks cardiac IKATP at a single site. This block might play a role in the beneficial and adverse effects of the drug.
  • Propafenone, a class I antiarrhythmic agent, inhibits several membrane currents, however, its effect on ATP-sensitive potassium current (IKATP) of cerdiac cells have not been tested. We evaluated the blocking effect of 0.1 to 100 uM propafenone on the whole cell IKATP as triggered by dinitrophenol in aduld rabbit isolated atrial and ventricular cardiomyocytes. It is concluded that propafenone blocks cardiac IKATP at a single site. This block might play a role in the beneficial and adverse effects of the drug. (en)
Title
  • Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes.
  • Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes. (en)
skos:prefLabel
  • Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes.
  • Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes. (en)
skos:notation
  • RIV/00216224:14110/99:00001308!RIV/2002/GA0/141102/N
http://linked.open.../vavai/riv/strany
  • 223
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/97/0043)
http://linked.open...iv/cisloPeriodika
  • 2-3
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http://linked.open...aciTvurceVysledku
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  • 751482
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/99:00001308
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  • Antiarrhythmic; Propafenone; K+ channel; ATP-sensitive; Cardiomyocyte; Ventricle. (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [EA05C5146810]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Pharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 373
http://linked.open...iv/tvurceVysledku
  • Šimurda, Jiří
  • Šimurdová, Milena
  • Christé, Georg
  • Forrat, Rémi
  • Tebbakh, Habiba
issn
  • 0014-2999
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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