About: Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired

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About: Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CVID is a primary immunodeficiency syndrome comprising a heterogeneous group of patients with hypogammaglobulinaemia and defective formation of specific antibodies. Previous studies demonstrated defective T cell responsiveness to antigen in a major subgroup of patients. In the present study we investigated the capacity of peripheral blood monocytes and Epstein-Barr virus (EBV)-transformed B cell lines from seven patients with CVID, including two patients expressing an extended MHC haplotype described to be associated with CVID, to present antigen (Tet. Tox.) to CD4(+) antigen-specific T cell lines from healthy controls. The results presented show an unimpaired capacity of peripheral blood monocytes to present antigen in all patients studied. In addition, the present study demonstrates for the first time that CVID B cells function normally as antigen-presenting cells (APC). CVID is a primary immunodeficiency syndrome comprising a heterogeneous group of patients with hypogammaglobulinaemia and defective formation of specific antibodies. Previous studies demonstrated defective T cell responsiveness to antigen in a major subgroup of patients. In the present study we investigated the capacity of peripheral blood monocytes and Epstein-Barr virus (EBV)-transformed B cell lines from seven patients with CVID, including two patients expressing an extended MHC haplotype described to be associated with CVID, to present antigen (Tet. Tox.) to CD4(+) antigen-specific T cell lines from healthy controls. The results presented show an unimpaired capacity of peripheral blood monocytes to present antigen in all patients studied. In addition, the present study demonstrates for the first time that CVID B cells function normally as antigen-presenting cells (APC). (en)
Title	Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired (en)
skos:prefLabel	Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired (en)
skos:notation	RIV/00216224:14110/97:00030213!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Thon, Vojtěch Lokaj, Jindřich Litzman, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	792809
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/97:00030213
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	common variable immunodeficiency; antigen presentation; B cells; monocytes (en)
http://linked.open.../riv/klicoveSlovo	common variable immunodeficiency antigen presentation B cells monocytes
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[660E0DE71D7B]
http://linked.open...i/riv/nazevZdroje	Clin.Exp.Immunol.
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	1997
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Litzman, Jiří Lokaj, Jindřich Thon, Vojtěch Eggenbauer, H. Fischer, M. B. Wolf, H. M.
http://linked.open...ain/vavai/riv/wos	A1997WR92700001
issn	0009-9104
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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