About: Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency     Goto   Sponge   NotDistinct   Permalink

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  • The patients included in this study belong to a subset of common variable immunodeficiency (CVID) patients whose peripheral blood T cells have a T cell receptor (TCR)-mediated activation defect leading to impaired expression of the interleukin (IL)-2 gene upon stimulation with recall antigens (tetanus toxoid, Escherichia coli) or superantigens (staphy lococcal enterotoxins). In the present report we demonstrate that the patients' peripheral blood T cells failed to generate the second messenger inositol 1,4,5-trisphosphate (Ins(1,4,5)P-3) following stimulation with superantigen or mAb specific for the monomorphic region of the TCR beta-chain. Patients' T cell lines were also impaired in generating Ins(1,4,5)P, when stimulated with tetanus toxoid-pulsed autologous monocytes. Addition of a second or third co-stimulatory signal provided by recombinant IL-2, CD28 or both had no effect on the Ins(1,4)P-3 formation of the patients' antigen-driven T cell lines.
  • The patients included in this study belong to a subset of common variable immunodeficiency (CVID) patients whose peripheral blood T cells have a T cell receptor (TCR)-mediated activation defect leading to impaired expression of the interleukin (IL)-2 gene upon stimulation with recall antigens (tetanus toxoid, Escherichia coli) or superantigens (staphy lococcal enterotoxins). In the present report we demonstrate that the patients' peripheral blood T cells failed to generate the second messenger inositol 1,4,5-trisphosphate (Ins(1,4,5)P-3) following stimulation with superantigen or mAb specific for the monomorphic region of the TCR beta-chain. Patients' T cell lines were also impaired in generating Ins(1,4,5)P, when stimulated with tetanus toxoid-pulsed autologous monocytes. Addition of a second or third co-stimulatory signal provided by recombinant IL-2, CD28 or both had no effect on the Ins(1,4)P-3 formation of the patients' antigen-driven T cell lines. (en)
Title
  • Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency
  • Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency (en)
skos:prefLabel
  • Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency
  • Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency (en)
skos:notation
  • RIV/00216224:14110/96:00035801!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 820411
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/96:00035801
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • T cell activation; common variable immunodeficiency; T cell receptor; inositol phosphates (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [0D2F7CF9C60A]
http://linked.open...i/riv/nazevZdroje
  • EUROPEAN JOURNAL OF IMMUNOLOGY
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 26
http://linked.open...iv/tvurceVysledku
  • Thon, Vojtěch
  • Eggenbauer, H.
  • Eibl, M. M.
  • Fischer, M. B.
  • Hauber, I.
  • Wolf, H. M.
  • Sasgary, M.
http://linked.open...ain/vavai/riv/wos
  • A1996UD13800035
issn
  • 0014-2980
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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