Attributes | Values |
---|
rdf:type
| |
Description
| - A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cells to tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results.
- A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cells to tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results. (en)
|
Title
| - THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
- THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY (en)
|
skos:prefLabel
| - THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
- THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY (en)
|
skos:notation
| - RIV/00216224:14110/94:00035805!RIV10-MSM-14110___
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| |
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/94:00035805
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - COMMON VARIABLE IMMUNODEFICIENCY; ANTIBODY DEFICIENCY; EFFECT OF CD28 IN CVID; EARLY T CELL ACTIVATION DEFECT; IMPAIRED RESPONSE TO RECALL ANTIGENS IN CVID T CELLS (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| - CLINICAL AND EXPERIMENTAL IMMUNOLOGY
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Litzman, Jiří
- Lokaj, Jindřich
- Thon, Vojtěch
- Vogel, E.
- Eggenbauer, H.
- Eibl, M. M.
- Fischer, M. B.
- Mannhalter, J. W.
- Wolf, H. M.
|
http://linked.open...ain/vavai/riv/wos
| |
issn
| |
number of pages
| |
http://localhost/t...ganizacniJednotka
| |