About: THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

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About: THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cells to tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results. A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cells to tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results. (en)
Title	THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY (en)
skos:prefLabel	THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY (en)
skos:notation	RIV/00216224:14110/94:00035805!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Thon, Vojtěch Lokaj, Jindřich Litzman, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	860273
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/94:00035805
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	COMMON VARIABLE IMMUNODEFICIENCY; ANTIBODY DEFICIENCY; EFFECT OF CD28 IN CVID; EARLY T CELL ACTIVATION DEFECT; IMPAIRED RESPONSE TO RECALL ANTIGENS IN CVID T CELLS (en)
http://linked.open.../riv/klicoveSlovo	ANTIBODY DEFICIENCY COMMON VARIABLE IMMUNODEFICIENCY EARLY T CELL ACTIVATION DEFECT EFFECT OF CD28 IN CVID IMPAIRED RESPONSE TO RECALL ANTIGENS IN CVID T CELLS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[ADDAF15216C7]
http://linked.open...i/riv/nazevZdroje	CLINICAL AND EXPERIMENTAL IMMUNOLOGY
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	1994
http://linked.open...v/svazekPeriodika	95
http://linked.open...iv/tvurceVysledku	Litzman, Jiří Lokaj, Jindřich Thon, Vojtěch Vogel, E. Eggenbauer, H. Eibl, M. M. Fischer, M. B. Mannhalter, J. W. Wolf, H. M.
http://linked.open...ain/vavai/riv/wos	A1994MU82700003
issn	0009-9104
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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