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  • Tumor growth is controlled by natural antitumor immune responses alone or by augmented immune reactivity resulting from different forms of immunotherapy, which has demonstrated clinical benefit in numerous studies, although the overall percentage of patients with durable clinical responses remains limited. This is attributed to the heterogeneity of the disease, the inclusion of late-stage patients with no other treatment options and advanced tumor-associated immunosuppression, which may be consolidated by certain types of chemotherapy. Despite variable responsiveness to distinct types of immunotherapy, therapeutic cancer vaccination has shown meaningful efficacy for a variety of cancers. A key step during cancer vaccination involves the appropriate modeling of the functional state of dendritic cells (DCs) capable of co-delivering four critical signals for proper instruction of tumor antigen specific T cells.
  • Tumor growth is controlled by natural antitumor immune responses alone or by augmented immune reactivity resulting from different forms of immunotherapy, which has demonstrated clinical benefit in numerous studies, although the overall percentage of patients with durable clinical responses remains limited. This is attributed to the heterogeneity of the disease, the inclusion of late-stage patients with no other treatment options and advanced tumor-associated immunosuppression, which may be consolidated by certain types of chemotherapy. Despite variable responsiveness to distinct types of immunotherapy, therapeutic cancer vaccination has shown meaningful efficacy for a variety of cancers. A key step during cancer vaccination involves the appropriate modeling of the functional state of dendritic cells (DCs) capable of co-delivering four critical signals for proper instruction of tumor antigen specific T cells. (en)
Title
  • Immune adjuvants as critical guides directing immunity triggered by therapeutic cancer vaccines
  • Immune adjuvants as critical guides directing immunity triggered by therapeutic cancer vaccines (en)
skos:prefLabel
  • Immune adjuvants as critical guides directing immunity triggered by therapeutic cancer vaccines
  • Immune adjuvants as critical guides directing immunity triggered by therapeutic cancer vaccines (en)
skos:notation
  • RIV/00216224:14110/14:00080091!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(EE2.3.20.0012), P(LM2011017)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 20532
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00080091
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • costimulation; homing signal; immune adjuvants; polarizing signal; therapeutic cancer vaccines (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [8CD836F9A16F]
http://linked.open...i/riv/nazevZdroje
  • Cytotherapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 16
http://linked.open...iv/tvurceVysledku
  • Michálek, Jaroslav
  • Schijns, Virgil
  • Dobrovolskiene, Neringa T.
  • Tartour, Eric
  • Stathopoulos, Apostolos
  • Strioga, Marius M.
http://linked.open...ain/vavai/riv/wos
  • 000333438000002
issn
  • 1465-3249
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.jcyt.2013.09.008
http://localhost/t...ganizacniJednotka
  • 14110
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