About: Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice     Goto   Sponge   NotDistinct   Permalink

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  • Activities of the endocannabinoid system are believed to be substantially involved in psychostimulant and opioid addiction. Nevertheless, interactions between cannabinoid and opioid systems are not yet fully understood. Thus, the aim of the present study was to investigate the interaction between morphine and the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) in behavioural sensitisation. Sensitisation occurs after repeated exposure to drugs of abuse including morphine and cannabinomimetics and it has been suggested to mediate craving and relapses. Male mice were randomly allocated into three groups and were seven times (from the 7th to 13th day of the experiment) administered drugs as follows: (a) n(1): vehicle at the dose of 10 ml/kg/day; (b) n(2): morphine at the dose of 10.0 mg/kg/day; (c) n(3): ACPA at the dose of 1.0 mg/kg/day.
  • Activities of the endocannabinoid system are believed to be substantially involved in psychostimulant and opioid addiction. Nevertheless, interactions between cannabinoid and opioid systems are not yet fully understood. Thus, the aim of the present study was to investigate the interaction between morphine and the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) in behavioural sensitisation. Sensitisation occurs after repeated exposure to drugs of abuse including morphine and cannabinomimetics and it has been suggested to mediate craving and relapses. Male mice were randomly allocated into three groups and were seven times (from the 7th to 13th day of the experiment) administered drugs as follows: (a) n(1): vehicle at the dose of 10 ml/kg/day; (b) n(2): morphine at the dose of 10.0 mg/kg/day; (c) n(3): ACPA at the dose of 1.0 mg/kg/day. (en)
Title
  • Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice
  • Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice (en)
skos:prefLabel
  • Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice
  • Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice (en)
skos:notation
  • RIV/00216224:14110/14:00078460!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 22276
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00078460
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • behavioural sensitisation; morphine; cannabinoids; ACPA; mice (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [47A4E35AB741]
http://linked.open...i/riv/nazevZdroje
  • Veterinarni Medicina
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 59
http://linked.open...iv/tvurceVysledku
  • Landa, Leoš
  • Šulcová, Alexandra
  • Máchalová, Alena
  • Šlais, Karel
http://linked.open...ain/vavai/riv/wos
  • 000342070600006
issn
  • 0375-8427
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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