About: DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia     Goto   Sponge   NotDistinct   Permalink

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  • The concept of leukaemic stem cells (LSCs) has been developed to explain the complex cellular hierarchy and biology of leukaemias and to screen for pivotal targets that can be employed to improve drug therapies through LSC eradication in these patients. Some of the newly discovered LSC markers seem to be expressed in a disease-specific manner and may thus serve as major research tools and diagnostic parameters. A useful LSC marker in chronic myeloid leukaemia (CML) appears to be CD26, also known as dipeptidylpeptidase IV. Expression of CD26 is largely restricted to CD34(+)/CD38(-) LSCs in BCR/ABL1(+) CML, but is not found on LSCs in other myeloid or lymphoid neoplasms, with the exception of lymphoid blast crisis of CML, BCR/ABL1(p210)+ acute lymphoblastic leukaemia, and a very few cases of acute myeloid leukaemia. Moreover, CD26 usually is not expressed on normal bone marrow (BM) stem cells.
  • The concept of leukaemic stem cells (LSCs) has been developed to explain the complex cellular hierarchy and biology of leukaemias and to screen for pivotal targets that can be employed to improve drug therapies through LSC eradication in these patients. Some of the newly discovered LSC markers seem to be expressed in a disease-specific manner and may thus serve as major research tools and diagnostic parameters. A useful LSC marker in chronic myeloid leukaemia (CML) appears to be CD26, also known as dipeptidylpeptidase IV. Expression of CD26 is largely restricted to CD34(+)/CD38(-) LSCs in BCR/ABL1(+) CML, but is not found on LSCs in other myeloid or lymphoid neoplasms, with the exception of lymphoid blast crisis of CML, BCR/ABL1(p210)+ acute lymphoblastic leukaemia, and a very few cases of acute myeloid leukaemia. Moreover, CD26 usually is not expressed on normal bone marrow (BM) stem cells. (en)
Title
  • DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia
  • DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia (en)
skos:prefLabel
  • DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia
  • DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia (en)
skos:notation
  • RIV/00216224:14110/14:00078413!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 12
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http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 12332
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00078413
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Diagnostics; leukaemia; leukaemic stem cells; stem cell; phenotyping (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [194ECBAE8BB5]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Clinical Investigation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 44
http://linked.open...iv/tvurceVysledku
  • Mayer, Jiří
  • Ráčil, Zdeněk
  • Holyoake, Tessa
  • Blatt, Katharina
  • Cerny-Reiterer, Sabine
  • Eisenwort, Gregor
  • Herrmann, Harald
  • Lion, Thomas
  • Sadovnik, Irina
  • Valent, Peter
http://linked.open...ain/vavai/riv/wos
  • 000345759100012
issn
  • 0014-2972
number of pages
http://bibframe.org/vocab/doi
  • 10.1111/eci.12368
http://localhost/t...ganizacniJednotka
  • 14110
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