About: Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical outcomes and are being used for preclinical drug evaluation, biomarker identification, biologic studies, and personalized medicine strategies. This article summarizes the current state of the art in this field, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and introduces a European consortium of PDX models. Significance: PDX models are increasingly used in translational cancer research. These models are useful for drug screening, biomarker development, and the preclinical evaluation of personalized medicine strategies. Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical outcomes and are being used for preclinical drug evaluation, biomarker identification, biologic studies, and personalized medicine strategies. This article summarizes the current state of the art in this field, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and introduces a European consortium of PDX models. Significance: PDX models are increasingly used in translational cancer research. These models are useful for drug screening, biomarker development, and the preclinical evaluation of personalized medicine strategies. (en)
Title	Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research (en)
skos:prefLabel	Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research (en)
skos:notation	RIV/00216224:14110/14:00078130!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Budinská, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	35920
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00078130
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HUMAN PANCREATIC-CANCER; TUMOR XENOGRAFTS; NUDE-MICE; COLORECTAL-CANCER; STEM-CELLS; IN-VIVO; PERSONALIZED CHEMOTHERAPY; THERAPEUTIC RESPONSE; IMMUNODEFICIENT MICE; DRUG DEVELOPMENT (en)
http://linked.open.../riv/klicoveSlovo	DRUG DEVELOPMENT HUMAN PANCREATIC-CANCER IMMUNODEFICIENT MICE NUDE-MICE PERSONALIZED CHEMOTHERAPY THERAPEUTIC RESPONSE TUMOR XENOGRAFTS IN-VIVO COLORECTAL-CANCER STEM-CELLS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[869143C6F16B]
http://linked.open...i/riv/nazevZdroje	Cancer Discovery
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Budinská, Eva Amant, Frederic Jonkers, Jos Biankin, Andrew V. Byrne, Annete T. Caldas, Carlos Clarke, Robert B. Hidalgo, Manuel Jong, Steven de Maelandsmo, Gundhild Mari Roman-Roman, Sergio Seoane, Joan Trusolino, Livio Villanueva, Alberto
http://linked.open...ain/vavai/riv/wos	000343121400023
issn	2159-8274
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1158/2159-8290.CD-14-0001
http://localhost/t...ganizacniJednotka	14110

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software