About: Altered Serum Cytokine Signature in Common Variable Immunodeficiency     Goto   Sponge   NotDistinct   Permalink

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  • Purpose Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation. Methods To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of cytokine serum levels in 36 patients with CVID, 52 patients with selective IgA deficiency (IgAD), and 56 healthy volunteers. Results We show that CVID is associated with elevated serum levels of CXCL-10/IP-10, IL-1R antagonist, TNF-alpha, IL-10, IL-12 (p40), CCL-2/MCP-1, G-CSF, and CCL-11/eotaxin. The detected cytokine signature is consistent with an ongoing activation of cells of myeloid lineage.
  • Purpose Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation. Methods To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of cytokine serum levels in 36 patients with CVID, 52 patients with selective IgA deficiency (IgAD), and 56 healthy volunteers. Results We show that CVID is associated with elevated serum levels of CXCL-10/IP-10, IL-1R antagonist, TNF-alpha, IL-10, IL-12 (p40), CCL-2/MCP-1, G-CSF, and CCL-11/eotaxin. The detected cytokine signature is consistent with an ongoing activation of cells of myeloid lineage. (en)
Title
  • Altered Serum Cytokine Signature in Common Variable Immunodeficiency
  • Altered Serum Cytokine Signature in Common Variable Immunodeficiency (en)
skos:prefLabel
  • Altered Serum Cytokine Signature in Common Variable Immunodeficiency
  • Altered Serum Cytokine Signature in Common Variable Immunodeficiency (en)
skos:notation
  • RIV/00216224:14110/14:00077503!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • I
http://linked.open...iv/cisloPeriodika
  • 8
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  • 2246
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00077503
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  • Common variable immunodeficiency; IgA deficiency; cytokine; lymphocyte activation (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [A514A9A1602B]
http://linked.open...i/riv/nazevZdroje
  • Journal of Clinical Immunology
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  • 34
http://linked.open...iv/tvurceVysledku
  • Litzman, Jiří
  • Vlková, Marcela
  • Nechvátalová, Jana
  • Hel, Zdenek
  • Huijbregts, Richard P. H.
  • Xu, Jun
http://linked.open...ain/vavai/riv/wos
  • 000344780000012
issn
  • 0271-9142
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s10875-014-0099-z
http://localhost/t...ganizacniJednotka
  • 14110
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