About: MicroRNA profiling of activated and tolerogenic human dendritic cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: MicroRNA profiling of activated and tolerogenic human dendritic cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dendritic cells (DCs) belong to the immune system and are particularly studied for their potential to direct either an activated or tolerogenic immune response. The roles of microRNAs (miRNAs) in posttranscriptional gene expression regulation are being increasingly investigated. This study's aim is to evaluate the miRNAs' expression changes in prepared human immature (iDCs), activated (aDCs), and tolerogenic dendritic cells (tDCs). The dendritic cells were prepared using GM-CSF and IL-4 (iDC) and subsequently maturated by adding LPS and IFN-gamma(aDC) or IL-10 and TGF-beta(tDC). Surface markers, cytokine profiles, and miRNA profiles were evaluated in iDC, tDC, and aDC at 6 h and 24 h of maturation. We identified 4 miRNAs (miR-7, miR-9, miR-155 and miR-182), which were consistently overexpressed in aDC after 6 h and 24 h of maturation and 3 miRNAs (miR-17, miR-133b, and miR-203) and miR-23b cluster solely expressed in tDC. Dendritic cells (DCs) belong to the immune system and are particularly studied for their potential to direct either an activated or tolerogenic immune response. The roles of microRNAs (miRNAs) in posttranscriptional gene expression regulation are being increasingly investigated. This study's aim is to evaluate the miRNAs' expression changes in prepared human immature (iDCs), activated (aDCs), and tolerogenic dendritic cells (tDCs). The dendritic cells were prepared using GM-CSF and IL-4 (iDC) and subsequently maturated by adding LPS and IFN-gamma(aDC) or IL-10 and TGF-beta(tDC). Surface markers, cytokine profiles, and miRNA profiles were evaluated in iDC, tDC, and aDC at 6 h and 24 h of maturation. We identified 4 miRNAs (miR-7, miR-9, miR-155 and miR-182), which were consistently overexpressed in aDC after 6 h and 24 h of maturation and 3 miRNAs (miR-17, miR-133b, and miR-203) and miR-23b cluster solely expressed in tDC. (en)
Title	MicroRNA profiling of activated and tolerogenic human dendritic cells MicroRNA profiling of activated and tolerogenic human dendritic cells (en)
skos:prefLabel	MicroRNA profiling of activated and tolerogenic human dendritic cells MicroRNA profiling of activated and tolerogenic human dendritic cells (en)
skos:notation	RIV/00216224:14110/14:00077328!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(NT13514), P(NT13547)
http://linked.open...iv/cisloPeriodika	259689
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Veselková, Zuzana Slabý, Ondřej Meli, Albano Michálek, Jaroslav Héžová, Renata
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	29207
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00077328
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNA; dendritic cells; expression profiling (en)
http://linked.open.../riv/klicoveSlovo	dendritic cells expression profiling microRNA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[AF209607CEB8]
http://linked.open...i/riv/nazevZdroje	Mediators of Inflammation
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Study od epithelial-to-mesenchymal transition associated microRNAs and genes as potential markers for prediction of risk and early detection of metastatic disease in renal cell carcinoma patients MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	2014
http://linked.open...iv/tvurceVysledku	Michálek, Jaroslav Slabý, Ondřej Héžová, Renata Meli, Albano Štumpfová, Zuzana
http://linked.open...ain/vavai/riv/wos	000334283100001
issn	0962-9351
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2014/259689
http://localhost/t...ganizacniJednotka	14110

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 77 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software