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Description
| - Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein%22 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n = 51)), and in 155 healthy controls. Biomarkers were measured at diagnosis and compared with disease characteristics. Six significant correlations were found: 1) BALF TFF3 level was associated with HRCT interstitial •score in IPF (P=0.052); 2) BALF PSP94 level with prognosis of sarcoidosis (P=0.035); 3) BALF SP-A level with pulmonary functions in IPF (P=0.032); 4) BALF SP-D and TT3 with IPF mortality (P=0.049 and 0.017, respectively); 5) serum TT3 level with COPD mortality (P=0.
- Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein%22 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n = 51)), and in 155 healthy controls. Biomarkers were measured at diagnosis and compared with disease characteristics. Six significant correlations were found: 1) BALF TFF3 level was associated with HRCT interstitial •score in IPF (P=0.052); 2) BALF PSP94 level with prognosis of sarcoidosis (P=0.035); 3) BALF SP-A level with pulmonary functions in IPF (P=0.032); 4) BALF SP-D and TT3 with IPF mortality (P=0.049 and 0.017, respectively); 5) serum TT3 level with COPD mortality (P=0. (en)
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Title
| - Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease
- Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease (en)
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skos:prefLabel
| - Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease
- Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease (en)
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skos:notation
| - RIV/00216224:14110/14:00077137!RIV15-MSM-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/14:00077137
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - idiopathic pulmonary fibrosis; sarcoidosis; chronic pulmonary obstructive disease (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Doubek, Michael
- Skřičková, Jana
- Mazoch, Jiří
- Doubková, Martina
- Karpisek, Michal
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http://localhost/t...ganizacniJednotka
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