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  • Aim: The FIRST registry aimed to compare patients with atrial fibrillation treated with dabigatran or warfarin. Methods: The study was performed in 10 centres in the Czech Republic. Results: Upon enrolment, 33.2% and 35.6% of patients respectively showed sinus rhythm. The last dose of warfarin before changing to dabigatran was higher than the maintenance dose 6.4 ± 4.3 mg vs. 4.6 ± 3.2 mg (p < 0.001). The patients did not differ in the CHA2DS2-VASc score. The principal difference was in the HAS BLED score: 55.3% of patients treated with dabigatran demonstrated a score of three or more while only 33.5% of those treated with warfarin did (p < 0.001). In 14.7% of patients treated with dabigatran, serious bleeding was observed during the previous treatment with warfarin. In patients treated with warfarin serious bleeding occurred in 2.0%. The most frequent reason (56.6%) for changing over to dabigatran was the impossibility to maintain INR within the therapeutic range.
  • Aim: The FIRST registry aimed to compare patients with atrial fibrillation treated with dabigatran or warfarin. Methods: The study was performed in 10 centres in the Czech Republic. Results: Upon enrolment, 33.2% and 35.6% of patients respectively showed sinus rhythm. The last dose of warfarin before changing to dabigatran was higher than the maintenance dose 6.4 ± 4.3 mg vs. 4.6 ± 3.2 mg (p < 0.001). The patients did not differ in the CHA2DS2-VASc score. The principal difference was in the HAS BLED score: 55.3% of patients treated with dabigatran demonstrated a score of three or more while only 33.5% of those treated with warfarin did (p < 0.001). In 14.7% of patients treated with dabigatran, serious bleeding was observed during the previous treatment with warfarin. In patients treated with warfarin serious bleeding occurred in 2.0%. The most frequent reason (56.6%) for changing over to dabigatran was the impossibility to maintain INR within the therapeutic range. (en)
Title
  • The First Registry. Comparison of anticoagulant treatment in patients with atrial fibrillation
  • The First Registry. Comparison of anticoagulant treatment in patients with atrial fibrillation (en)
skos:prefLabel
  • The First Registry. Comparison of anticoagulant treatment in patients with atrial fibrillation
  • The First Registry. Comparison of anticoagulant treatment in patients with atrial fibrillation (en)
skos:notation
  • RIV/00216224:14110/14:00076143!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 16961
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00076143
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Atrial fibrillation; Bleeding; Dabigatran; Risk; Warfarin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CA - Kanada
http://linked.open...ontrolniKodProRIV
  • [5918916DB844]
http://linked.open...i/riv/nazevZdroje
  • Experimental and Clinical Cardiology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 20
http://linked.open...iv/tvurceVysledku
  • Jarkovský, Jiří
  • Lábrová, Růžena
  • Souček, Miroslav
  • Vítovec, Jiří
  • Špinar, Jindřich
  • Špinarová, Lenka
  • Špác, Jiří
  • Šišáková, Martina
  • Ondrejková, Alena
issn
  • 1205-6626
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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