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| Description
| - Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication. Patients and Methods Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent in situ hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models.
- Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication. Patients and Methods Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent in situ hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models. (en)
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| Title
| - Cytogenetic Prognostication Within Medulloblastoma Subgroups
- Cytogenetic Prognostication Within Medulloblastoma Subgroups (en)
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| skos:prefLabel
| - Cytogenetic Prognostication Within Medulloblastoma Subgroups
- Cytogenetic Prognostication Within Medulloblastoma Subgroups (en)
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| skos:notation
| - RIV/00216224:14110/14:00076105!RIV15-MSM-14110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/14:00076105
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - NEUROTROPHIN RECEPTOR TRKC; CHILDHOOD MEDULLOBLASTOMA; BRAIN-TUMORS; MOLECULAR SUBGROUPS; RISK STRATIFICATION; PATHWAY ACTIVATION; OUTCOME PREDICTION; MYCN AMPLIFICATION; TP53 MUTATIONS; POOR-PROGNOSIS (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of clinical oncology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Zitterbart, Karel
- …
- Křen, Leoš
- Hauser, Peter
- Albrecht, Steffen
- Antonellis, Pasqualino De
- Bailey, Simon
- Bognár, László
- Cavalli, Florence M.G.
- Chan, Jennifer A.
- Cinalli, Giuseppe
- Cooper, Michael K.
- Di Rocco, Concezio
- Dubuc, Adrian M.
- Eberhart, Charles G.
- Fan, Xing
- Faria, Claudia C.
- Fontebasso, Adam
- Fouladi, Maryam
- Garami, Miklos
- Garzia, Livia
- Gupta, Nalin
- Jones, David T.W.
- Jung, Shin
- Klekner, Almos
- Kool, Marcel
- Korshunov, Andrey
- Kumabe, Toshihiro
- Lach, Boleslaw
- Liau, Linda M.
- Lindsey, Janet C.
- Luu, Betty
- Mack, Stephen C.
- Massimi, Luca
- Michiels, Erna M.C.
- Morrissy, Sorana A.
- Muraszko, Karin M.
- Northcott, Paul A.
- Peacock, John
- Phillips, Joanna J.
- Ra, Young Shin
- Ramaswamy, Vijay
- Remke, Marc
- Robinson, Shenandoah
- Rolider, Adi
- Saad, Ali G.
- Scherer, Stephen W.
- Schuller, Ulrich
- Shih, David J.H.
- Thompson, Reid C.
- Tominaga, Teiji
- Vibhakar, Rajeev
- Wang, Xin
- Wechsler-Reya, Robert J.
- Wu, Xiaochong
- Yao, Yuan
- Zollo, Massimo
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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