About: Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation     Goto   Sponge   NotDistinct   Permalink

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  • Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds.
  • Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds. (en)
Title
  • Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation
  • Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation (en)
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  • Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation
  • Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation (en)
skos:notation
  • RIV/00216224:14110/14:00075701!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • 9559
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  • RIV/00216224:14110/14:00075701
http://linked.open...riv/jazykVysledku
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  • USNEA-LONGISSIMA; LICHEN; ACID; PULMONARIA (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [128709A257ED]
http://linked.open...i/riv/nazevZdroje
  • Journal of Natural Products
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http://linked.open...v/svazekPeriodika
  • 77
http://linked.open...iv/tvurceVysledku
  • Slaninová, Iva
  • Kopp, Brigitte
  • Krupitza, Georg
  • Páchniková, Gabriela
  • Bauer, Rudolf
  • Franzblau, Scott G.
  • Kang, Avinash Kaur
  • Kretschmer, Nadine
  • Pauli, Guido F.
  • Schinkovitz, Andreas
  • Urban, Ernst
  • Wang, Yuehong
  • Zehl, Martin
http://linked.open...ain/vavai/riv/wos
  • 000335127200046
issn
  • 0163-3864
number of pages
http://bibframe.org/vocab/doi
  • 10.1021/np4008574
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  • 14110
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