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  • The current worldwide epidemic of metabolic syndrome represents an urgent challenge for new pharmacotherapy development. There is growing evidence of multiple metabolic dysregulations contributing to the development of the pathophysiological processes underlying metabolic syndrome. The adipose tissue metabolism and its endocrine activity is one of the key mechanisms believed to provide new targets for pharmacotherapy. The aim of this chapter is to provide a survey on metabolic syndrome pathophysiology, etiology and hypotheses of its development with special attention focused on insulin resistance, inflammatory processes and endocrine activity of the adipose tissue. Specific adipokines secreted by the body fat have multiple effects on the energy metabolism and can either support or suppress insulin signaling. Their pharmacological exploitation may lead to development of new treatments of insulin resistance and metabolic syndrome.
  • The current worldwide epidemic of metabolic syndrome represents an urgent challenge for new pharmacotherapy development. There is growing evidence of multiple metabolic dysregulations contributing to the development of the pathophysiological processes underlying metabolic syndrome. The adipose tissue metabolism and its endocrine activity is one of the key mechanisms believed to provide new targets for pharmacotherapy. The aim of this chapter is to provide a survey on metabolic syndrome pathophysiology, etiology and hypotheses of its development with special attention focused on insulin resistance, inflammatory processes and endocrine activity of the adipose tissue. Specific adipokines secreted by the body fat have multiple effects on the energy metabolism and can either support or suppress insulin signaling. Their pharmacological exploitation may lead to development of new treatments of insulin resistance and metabolic syndrome. (en)
Title
  • Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite
  • Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite (en)
skos:prefLabel
  • Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite
  • Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite (en)
skos:notation
  • RIV/00216224:14110/14:00075512!RIV15-MSM-14110___
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  • 1651
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  • RIV/00216224:14110/14:00075512
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  • metabolic syndrome; adipokines; leptin; adiponectin; resistin; AFABP (en)
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  • [D2EFDCD45FB7]
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  • New York
http://linked.open...vEdiceCisloSvazku
  • Human Anatomy and Physiology
http://linked.open...i/riv/nazevZdroje
  • Appetite: Regulation, Use of Stimulants and Cultural and Biological Influences
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  • Kučerová, Jana
  • Horská, Kateřina
  • Kotolová, Hana
number of pages
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  • Nova Science Publishers
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  • 9781631172434
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  • 14110
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